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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

Fig. 4

Maternal HFD consumption at gestation or lactation independently alters miRNAs and lipid-related gene expression. Body weight (a), adiposity (b), caloric intake (c), fasting glucose (d) and serum lipids (CHOL and TAG - e), mRNA levels (qRT-PCR) of hepatic Cpt1a and Acadvl (f), and Agpat and Gpam (g), hepatic total lipid content (h), microRNA level (qRT-PCR) of hepatic miR-122 and miR-370 (i), correlation analysis between hepatic miR-122 and serum TAG (j) from recently weaned unfostered offspring (CC and HH) and crossfostered offspring (CH and HC) at d28. For relative gene expression analysis, β-Actin and U6snRNA were used as endogenous controls. One-way ANOVA was used in all analyses to compare CC, CH, HH and HC groups. Values are means (n = 5–8) + - SEM. Different letters indicate statistical significance between groups (p ≤ 0.05)

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Nutrition & Metabolism

ISSN: 1743-7075

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