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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

Fig. 6

Maternal HFD consumption leads offspring to increased metabolic complications when exposed to HFD in adult life. Weight gain (a), body weight (b), adiposity (c), caloric intake (d), serum parameters (CHOL, TAG and leptin) (e), fasting glucose (f), area under curve (AUC) of GTT (g) and PTT (h), glucose clearance during ITT (i), mRNA levels (qRT-PCR) of hepatic Cpt1a and Acadvl (j) and Agpat and Gpam (k), total hepatic lipid content (l) from adult offspring after exposure to HFD for 40 days at d82 (CC-HF and HH-HF groups). For relative gene expression analysis, β-Actin was used as endogenous control. Values are means (n = 5–8) + - SEM. Student's t-test was used in all analyses to compare CC-HF and HH-HF groups. Different letters indicate statistical significance between groups (p ≤ 0.05)

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Nutrition & Metabolism

ISSN: 1743-7075

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