Fig. 2
From: Resistance training to improve type 2 diabetes: working toward a prescription for the future
Biguanides such as metformin exert their action via inhibition of complex I, mitochondrial glycerophosphate dehydrogenase and ATP synthase, thereby increasing [AMP]/[ATP] ratio, activating AMPK and increasing insulin sensitivity. ET acts in part through the same pathway, suggesting that these two stimuli could act synergistically. The effect of a RT regimen on individuals with T2D currently taking metformin and other anti-diabetic drugs remains to be determined