TY - JOUR AU - Evan, G. I. AU - Vousden, K. H. PY - 2001 DA - 2001// TI - Proliferation, cell cycle and apoptosis in cancer JO - Nature VL - 411 UR - https://doi.org/10.1038/35077213 DO - 10.1038/35077213 ID - Evan2001 ER - TY - JOUR AU - Hanahan, D. AU - Weinberg, R. A. PY - 2011 DA - 2011// TI - Hallmarks of cancer: the next generation JO - Cell VL - 144 UR - https://doi.org/10.1016/j.cell.2011.02.013 DO - 10.1016/j.cell.2011.02.013 ID - Hanahan2011 ER - TY - JOUR AU - Ferreira, C. G. AU - Epping, M. AU - Kruyt, F. A. AU - Giaccone, G. PY - 2002 DA - 2002// TI - Apoptosis: target of cancer therapy JO - Clin Cancer Res VL - 8 ID - Ferreira2002 ER - TY - JOUR AU - Elmore, S. PY - 2007 DA - 2007// TI - Apoptosis: a review of programmed cell death JO - Toxicol Pathol VL - 35 UR - https://doi.org/10.1080/01926230701320337 DO - 10.1080/01926230701320337 ID - Elmore2007 ER - TY - JOUR AU - Satyavati, G. V. PY - 1988 DA - 1988// TI - Gum guggul (Commiphora mukul)--the success story of an ancient insight leading to a modern discovery JO - Indian J Med Res VL - 87 ID - Satyavati1988 ER - TY - STD TI - Satyavati GV, Dwarakanath C, Tripathi SN: Experimental studies on the hypocholesterolemic effect of Commiphora mukul Engl. (Guggul). 1969. Indian J Med Res. 2013; 137:14 p following p403. ID - ref6 ER - TY - JOUR AU - Sinal, C. J. AU - Gonzalez, F. J. PY - 2002 DA - 2002// TI - Guggulsterone: an old approach to a new problem JO - Trends Endocrinol Metab VL - 13 UR - https://doi.org/10.1016/S1043-2760(02)00640-9 DO - 10.1016/S1043-2760(02)00640-9 ID - Sinal2002 ER - TY - JOUR AU - Urizar, N. L. AU - Liverman, A. B. AU - Dodds, D. T. AU - Silva, F. V. AU - Ordentlich, P. AU - Yan, Y. AU - Gonzalez, F. J. AU - Heyman, R. A. AU - Mangelsdorf, D. J. AU - Moore, D. D. PY - 2002 DA - 2002// TI - A natural product that lowers cholesterol as an antagonist ligand for FXR JO - Science VL - 296 UR - https://doi.org/10.1126/science.1072891 DO - 10.1126/science.1072891 ID - Urizar2002 ER - TY - JOUR AU - Wu, J. AU - Xia, C. AU - Meier, J. AU - Li, S. AU - Hu, X. AU - Lala, D. S. PY - 2002 DA - 2002// TI - The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor JO - Mol Endocrinol VL - 16 UR - https://doi.org/10.1210/mend.16.7.0894 DO - 10.1210/mend.16.7.0894 ID - Wu2002 ER - TY - JOUR AU - Owsley, E. AU - Chiang, J. Y. PY - 2003 DA - 2003// TI - Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene JO - Biochem Biophys Res Commun VL - 304 UR - https://doi.org/10.1016/S0006-291X(03)00551-5 DO - 10.1016/S0006-291X(03)00551-5 ID - Owsley2003 ER - TY - JOUR AU - Cui, J. AU - Huang, L. AU - Zhao, A. AU - Lew, J. L. AU - Yu, J. AU - Sahoo, S. AU - Meinke, P. T. AU - Royo, I. AU - Pelaez, F. AU - Wright, S. D. PY - 2003 DA - 2003// TI - Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M209323200 DO - 10.1074/jbc.M209323200 ID - Cui2003 ER - TY - JOUR AU - Gottardi, A. AU - Dumonceau, J. M. AU - Bruttin, F. AU - Vonlaufen, A. AU - Morard, I. AU - Spahr, L. AU - Rubbia-Brandt, L. AU - Frossard, J. L. AU - Dinjens, W. N. AU - Rabinovitch, P. S. AU - Hadengue, A. PY - 2006 DA - 2006// TI - Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro JO - Mol Cancer VL - 5 UR - https://doi.org/10.1186/1476-4598-5-48 DO - 10.1186/1476-4598-5-48 ID - Gottardi2006 ER - TY - JOUR AU - Ahn, K. S. AU - Sethi, G. AU - Sung, B. AU - Goel, A. AU - Ralhan, R. AU - Aggarwal, B. B. PY - 2008 DA - 2008// TI - Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-6696 DO - 10.1158/0008-5472.CAN-07-6696 ID - Ahn2008 ER - TY - JOUR AU - Kapoor, S. PY - 2008 DA - 2008// TI - Guggulsterone: a potent farnesoid X receptor antagonist and its rapidly evolving role as a systemic anticarcinogenic agent JO - Hepatology VL - 48 UR - https://doi.org/10.1002/hep.22601 DO - 10.1002/hep.22601 ID - Kapoor2008 ER - TY - JOUR AU - Peng, Z. AU - Raufman, J. P. AU - Xie, G. PY - 2012 DA - 2012// TI - Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0048461 DO - 10.1371/journal.pone.0048461 ID - Peng2012 ER - TY - JOUR AU - Guan, B. AU - Li, H. AU - Yang, Z. AU - Hoque, A. AU - Xu, X. PY - 2013 DA - 2013// TI - Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts JO - Cancer VL - 119 UR - https://doi.org/10.1002/cncr.27910 DO - 10.1002/cncr.27910 ID - Guan2013 ER - TY - JOUR AU - Deng, R. AU - Yang, D. AU - Radke, A. AU - Yang, J. AU - Yan, B. PY - 2007 DA - 2007// TI - The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism JO - J Pharmacol Exp Ther VL - 320 UR - https://doi.org/10.1124/jpet.106.113837 DO - 10.1124/jpet.106.113837 ID - Deng2007 ER - TY - JOUR AU - Szapary, P. O. AU - Wolfe, M. L. AU - Bloedon, L. T. AU - Cucchiara, A. J. AU - DerMarderosian, A. H. AU - Cirigliano, M. D. AU - Rader, D. J. PY - 2003 DA - 2003// TI - Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial JO - JAMA VL - 290 UR - https://doi.org/10.1001/jama.290.6.765 DO - 10.1001/jama.290.6.765 ID - Szapary2003 ER - TY - JOUR AU - Dev, S. PY - 1999 DA - 1999// TI - Ancient-modern concordance in Ayurvedic plants: some examples JO - Environ Health Perspect VL - 107 UR - https://doi.org/10.1289/ehp.99107783 DO - 10.1289/ehp.99107783 ID - Dev1999 ER - TY - JOUR AU - Nityanand, S. AU - Srivastava, J. S. AU - Asthana, O. P. PY - 1989 DA - 1989// TI - Clinical trials with gugulipid. A new hypolipidaemic agent JO - J Assoc Physicians India VL - 37 ID - Nityanand1989 ER - TY - JOUR AU - Singh, R. B. AU - Niaz, M. A. AU - Ghosh, S. PY - 1994 DA - 1994// TI - Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia JO - Cardiovasc Drugs Ther VL - 8 UR - https://doi.org/10.1007/BF00877420 DO - 10.1007/BF00877420 ID - Singh1994 ER - TY - JOUR AU - Beg, M. AU - Singhal, K. C. AU - Afzaal, S. PY - 1996 DA - 1996// TI - A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy JO - Indian J Physiol Pharmacol VL - 40 ID - Beg1996 ER - TY - JOUR AU - Urizar, N. L. AU - Moore, D. D. PY - 2003 DA - 2003// TI - GUGULIPID: a natural cholesterol-lowering agent JO - Annu Rev Nutr VL - 23 UR - https://doi.org/10.1146/annurev.nutr.23.011702.073102 DO - 10.1146/annurev.nutr.23.011702.073102 ID - Urizar2003 ER - TY - JOUR AU - Singh, S. V. AU - Choi, S. AU - Zeng, Y. AU - Hahm, E. R. AU - Xiao, D. PY - 2007 DA - 2007// TI - Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-0120 DO - 10.1158/0008-5472.CAN-07-0120 ID - Singh2007 ER - TY - JOUR AU - Shishodia, S. AU - Sethi, G. AU - Ahn, K. S. AU - Aggarwal, B. B. PY - 2007 DA - 2007// TI - Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products JO - Biochem Pharmacol VL - 74 UR - https://doi.org/10.1016/j.bcp.2007.03.026 DO - 10.1016/j.bcp.2007.03.026 ID - Shishodia2007 ER - TY - JOUR AU - Samudio, I. AU - Konopleva, M. AU - Safe, S. AU - McQueen, T. AU - Andreeff, M. PY - 2005 DA - 2005// TI - Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure JO - Mol Cancer Ther VL - 4 UR - https://doi.org/10.1158/1535-7163.MCT-05-0247 DO - 10.1158/1535-7163.MCT-05-0247 ID - Samudio2005 ER - TY - JOUR AU - Singh, S. V. AU - Zeng, Y. AU - Xiao, D. AU - Vogel, V. G. AU - Nelson, J. B. AU - Dhir, R. AU - Tripathi, Y. B. PY - 2005 DA - 2005// TI - Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak JO - Mol Cancer Ther VL - 4 UR - https://doi.org/10.1158/1535-7163.MCT-05-0223 DO - 10.1158/1535-7163.MCT-05-0223 ID - Singh2005 ER - TY - JOUR AU - Xiao, D. AU - Singh, S. V. PY - 2008 DA - 2008// TI - z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo JO - Mol Cancer Ther VL - 7 UR - https://doi.org/10.1158/1535-7163.MCT-07-0491 DO - 10.1158/1535-7163.MCT-07-0491 ID - Xiao2008 ER - TY - JOUR AU - Shishodia, S. AU - Aggarwal, B. B. PY - 2004 DA - 2004// TI - Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M408093200 DO - 10.1074/jbc.M408093200 ID - Shishodia2004 ER - TY - JOUR AU - Cheon, J. H. AU - Kim, J. S. AU - Kim, J. M. AU - Kim, N. AU - Jung, H. C. AU - Song, I. S. PY - 2006 DA - 2006// TI - Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis JO - Inflamm Bowel Dis VL - 12 UR - https://doi.org/10.1097/01.mib.0000235830.94057.c6 DO - 10.1097/01.mib.0000235830.94057.c6 ID - Cheon2006 ER - TY - JOUR AU - Ichikawa, H. AU - Aggarwal, B. B. PY - 2006 DA - 2006// TI - Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation JO - Clin Cancer Res VL - 12 UR - https://doi.org/10.1158/1078-0432.CCR-05-1749 DO - 10.1158/1078-0432.CCR-05-1749 ID - Ichikawa2006 ER - TY - JOUR AU - Choudhuri, R. AU - Degraff, W. AU - Gamson, J. AU - Mitchell, J. B. AU - Cook, J. A. PY - 2011 DA - 2011// TI - Guggulsterone-mediated enhancement of radiosensitivity in human tumor cell lines JO - Front Oncol VL - 1 UR - https://doi.org/10.3389/fonc.2011.00019 DO - 10.3389/fonc.2011.00019 ID - Choudhuri2011 ER - TY - JOUR AU - Macha, M. A. AU - Rachagani, S. AU - Gupta, S. AU - Pai, P. AU - Ponnusamy, M. P. AU - Batra, S. K. AU - Jain, M. PY - 2013 DA - 2013// TI - Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling JO - Cancer Lett VL - 341 UR - https://doi.org/10.1016/j.canlet.2013.07.037 DO - 10.1016/j.canlet.2013.07.037 ID - Macha2013 ER - TY - JOUR AU - Jiang, G. AU - Xiao, X. AU - Zeng, Y. AU - Nagabhushanam, K. AU - Majeed, M. AU - Xiao, D. PY - 2013 DA - 2013// TI - Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul JO - BMC Complement Altern Med VL - 13 UR - https://doi.org/10.1186/1472-6882-13-203 DO - 10.1186/1472-6882-13-203 ID - Jiang2013 ER - TY - JOUR AU - Macha, M. A. AU - Matta, A. AU - Chauhan, S. S. AU - Siu, K. W. AU - Ralhan, R. PY - 2011 DA - 2011// TI - Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-kappaB and STAT3 pathways in head and neck cancer cells JO - Carcinogenesis VL - 32 UR - https://doi.org/10.1093/carcin/bgq278 DO - 10.1093/carcin/bgq278 ID - Macha2011 ER - TY - JOUR AU - Leeman-Neill, R. J. AU - Wheeler, S. E. AU - Singh, S. V. AU - Thomas, S. M. AU - Seethala, R. R. AU - Neill, D. B. AU - Panahandeh, M. C. AU - Hahm, E. R. AU - Joyce, S. C. AU - Sen, M. PY - 2009 DA - 2009// TI - Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3 JO - Carcinogenesis VL - 30 UR - https://doi.org/10.1093/carcin/bgp211 DO - 10.1093/carcin/bgp211 ID - Leeman-Neill2009 ER - TY - JOUR AU - Aggarwal, B. B. AU - Shishodia, S. PY - 2006 DA - 2006// TI - Molecular targets of dietary agents for prevention and therapy of cancer JO - Biochem Pharmacol VL - 71 UR - https://doi.org/10.1016/j.bcp.2006.02.009 DO - 10.1016/j.bcp.2006.02.009 ID - Aggarwal2006 ER - TY - JOUR AU - Lee, J. Y. AU - Lee, K. T. AU - Lee, J. K. AU - Lee, K. H. AU - Jang, K. T. AU - Heo, J. S. AU - Choi, S. H. AU - Kim, Y. AU - Rhee, J. C. PY - 2011 DA - 2011// TI - Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion JO - Br J Cancer VL - 104 UR - https://doi.org/10.1038/bjc.2011.37 DO - 10.1038/bjc.2011.37 ID - Lee2011 ER - TY - JOUR AU - Ahn, D. W. AU - Seo, J. K. AU - Lee, S. H. AU - Hwang, J. H. AU - Lee, J. K. AU - Ryu, J. K. AU - Kim, Y. T. AU - Yoon, Y. B. PY - 2012 DA - 2012// TI - Enhanced antitumor effect of combination therapy with gemcitabine and guggulsterone in pancreatic cancer JO - Pancreas VL - 41 UR - https://doi.org/10.1097/MPA.0b013e318249d62e DO - 10.1097/MPA.0b013e318249d62e ID - Ahn2012 ER - TY - JOUR AU - Grandis, J. R. AU - Drenning, S. D. AU - Zeng, Q. AU - Watkins, S. C. AU - Melhem, M. F. AU - Endo, S. AU - Johnson, D. E. AU - Huang, L. AU - He, Y. AU - Kim, J. D. PY - 2000 DA - 2000// TI - Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo JO - Proc Natl Acad Sci U S A VL - 97 UR - https://doi.org/10.1073/pnas.97.8.4227 DO - 10.1073/pnas.97.8.4227 ID - Grandis2000 ER - TY - JOUR AU - Rubin Grandis, J. AU - Zeng, Q. AU - Drenning, S. D. PY - 2000 DA - 2000// TI - Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer JO - Laryngoscope VL - 110 UR - https://doi.org/10.1097/00005537-200005000-00016 DO - 10.1097/00005537-200005000-00016 ID - Rubin Grandis2000 ER - TY - JOUR AU - Grandis, J. R. AU - Drenning, S. D. AU - Chakraborty, A. AU - Zhou, M. Y. AU - Zeng, Q. AU - Pitt, A. S. AU - Tweardy, D. J. PY - 1998 DA - 1998// TI - Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro JO - J Clin Invest VL - 102 UR - https://doi.org/10.1172/JCI3785 DO - 10.1172/JCI3785 ID - Grandis1998 ER - TY - JOUR AU - Macha, M. A. AU - Matta, A. AU - Chauhan, S. AU - Siu, K. M. AU - Ralhan, R. PY - 2010 DA - 2010// TI - 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells JO - BMC Cancer VL - 10 UR - https://doi.org/10.1186/1471-2407-10-655 DO - 10.1186/1471-2407-10-655 ID - Macha2010 ER - TY - JOUR AU - Waes, C. AU - Chang, A. A. AU - Lebowitz, P. F. AU - Druzgal, C. H. AU - Chen, Z. AU - Elsayed, Y. A. AU - Sunwoo, J. B. AU - Rudy, S. F. AU - Morris, J. C. AU - Mitchell, J. B. PY - 2005 DA - 2005// TI - Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma JO - Int J Radiat Oncol Biol Phys VL - 63 UR - https://doi.org/10.1016/j.ijrobp.2005.05.007 DO - 10.1016/j.ijrobp.2005.05.007 ID - Waes2005 ER - TY - JOUR AU - Li, C. AU - Li, R. AU - Grandis, J. R. AU - Johnson, D. E. PY - 2008 DA - 2008// TI - Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells JO - Mol Cancer Ther VL - 7 UR - https://doi.org/10.1158/1535-7163.MCT-07-2444 DO - 10.1158/1535-7163.MCT-07-2444 ID - Li2008 ER - TY - JOUR AU - Leeman-Neill, R. J. AU - Seethala, R. R. AU - Singh, S. V. AU - Freilino, M. L. AU - Bednash, J. S. AU - Thomas, S. M. AU - Panahandeh, M. C. AU - Gooding, W. E. AU - Joyce, S. C. AU - Lingen, M. W. PY - 2011 DA - 2011// TI - Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma JO - Cancer Prev Res (Phila) VL - 4 UR - https://doi.org/10.1158/1940-6207.CAPR-10-0249 DO - 10.1158/1940-6207.CAPR-10-0249 ID - Leeman-Neill2011 ER - TY - JOUR AU - Guan, B. AU - Hoque, A. AU - Xu, X. PY - 2014 DA - 2014// TI - Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts JO - Front Biol (Beijing) VL - 9 UR - https://doi.org/10.1007/s11515-014-1289-z DO - 10.1007/s11515-014-1289-z ID - Guan2014 ER - TY - JOUR AU - Yamada, T. AU - Osawa, S. AU - Ikuma, M. AU - Kajimura, M. AU - Sugimoto, M. AU - Furuta, T. AU - Iwaizumi, M. AU - Sugimoto, K. PY - 2014 DA - 2014// TI - Guggulsterone, a plant-derived inhibitor of NF-TB, suppresses CDX2 and COX-2 expression and reduces the viability of esophageal adenocarcinoma cells JO - Digestion VL - 90 UR - https://doi.org/10.1159/000365750 DO - 10.1159/000365750 ID - Yamada2014 ER - TY - JOUR AU - Kelly, H. AU - Goldberg, R. M. PY - 2005 DA - 2005// TI - Systemic therapy for metastatic colorectal cancer: current options, current evidence JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.17.749 DO - 10.1200/JCO.2005.17.749 ID - Kelly2005 ER - TY - JOUR AU - An, M. J. AU - Cheon, J. H. AU - Kim, S. W. AU - Kim, E. S. AU - Kim, T. I. AU - Kim, W. H. PY - 2009 DA - 2009// TI - Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts JO - Cancer Lett VL - 279 UR - https://doi.org/10.1016/j.canlet.2009.01.026 DO - 10.1016/j.canlet.2009.01.026 ID - An2009 ER - TY - JOUR AU - Kim, E. S. AU - Hong, S. Y. AU - Lee, H. K. AU - Kim, S. W. AU - An, M. J. AU - Kim, T. I. AU - Lee, K. R. AU - Kim, W. H. AU - Cheon, J. H. PY - 2008 DA - 2008// TI - Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells JO - Oncol Rep VL - 20 ID - Kim2008 ER - TY - JOUR AU - Gottardi, A. AU - Touri, F. AU - Maurer, C. A. AU - Perez, A. AU - Maurhofer, O. AU - Ventre, G. AU - Bentzen, C. L. AU - Niesor, E. J. AU - Dufour, J. F. PY - 2004 DA - 2004// TI - The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer JO - Dig Dis Sci VL - 49 UR - https://doi.org/10.1023/B:DDAS.0000034558.78747.98 DO - 10.1023/B:DDAS.0000034558.78747.98 ID - Gottardi2004 ER - TY - JOUR AU - Lax, S. AU - Schauer, G. AU - Prein, K. AU - Kapitan, M. AU - Silbert, D. AU - Berghold, A. AU - Berger, A. AU - Trauner, M. PY - 2012 DA - 2012// TI - Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis JO - Int J Cancer VL - 130 UR - https://doi.org/10.1002/ijc.26293 DO - 10.1002/ijc.26293 ID - Lax2012 ER - TY - JOUR AU - Modica, S. AU - Murzilli, S. AU - Salvatore, L. AU - Schmidt, D. R. AU - Moschetta, A. PY - 2008 DA - 2008// TI - Nuclear bile acid receptor FXR protects against intestinal tumorigenesis JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-08-1791 DO - 10.1158/0008-5472.CAN-08-1791 ID - Modica2008 ER - TY - JOUR AU - Maran, R. R. AU - Thomas, A. AU - Roth, M. AU - Sheng, Z. AU - Esterly, N. AU - Pinson, D. AU - Gao, X. AU - Zhang, Y. AU - Ganapathy, V. AU - Gonzalez, F. J. AU - Guo, G. L. PY - 2009 DA - 2009// TI - Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development JO - J Pharmacol Exp Ther VL - 328 UR - https://doi.org/10.1124/jpet.108.145409 DO - 10.1124/jpet.108.145409 ID - Maran2009 ER - TY - JOUR AU - Althuis, M. D. AU - Dozier, J. M. AU - Anderson, W. F. AU - Devesa, S. S. AU - Brinton, L. A. PY - 2005 DA - 2005// TI - Global trends in breast cancer incidence and mortality 1973-1997 JO - Int J Epidemiol VL - 34 UR - https://doi.org/10.1093/ije/dyh414 DO - 10.1093/ije/dyh414 ID - Althuis2005 ER - TY - JOUR AU - Siegel, R. AU - DeSantis, C. AU - Virgo, K. AU - Stein, K. AU - Mariotto, A. AU - Smith, T. AU - Cooper, D. AU - Gansler, T. AU - Lerro, C. AU - Fedewa, S. PY - 2012 DA - 2012// TI - Cancer treatment and survivorship statistics, 2012 JO - CA Cancer J Clin VL - 62 UR - https://doi.org/10.3322/caac.21149 DO - 10.3322/caac.21149 ID - Siegel2012 ER - TY - JOUR AU - Gilmore, T. D. PY - 1997 DA - 1997// TI - Introduction: The Rel/NF-kappaB signal transduction pathway JO - Semin Cancer Biol VL - 8 UR - https://doi.org/10.1006/scbi.1997.0056 DO - 10.1006/scbi.1997.0056 ID - Gilmore1997 ER - TY - JOUR AU - Rayet, B. AU - Gelinas, C. PY - 1999 DA - 1999// TI - Aberrant rel/nfkb genes and activity in human cancer JO - Oncogene VL - 18 UR - https://doi.org/10.1038/sj.onc.1203221 DO - 10.1038/sj.onc.1203221 ID - Rayet1999 ER - TY - JOUR AU - Singh, R. P. AU - Dhanalakshmi, S. AU - Agarwal, C. AU - Agarwal, R. PY - 2005 DA - 2005// TI - Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy JO - Oncogene VL - 24 UR - https://doi.org/10.1038/sj.onc.1208276 DO - 10.1038/sj.onc.1208276 ID - Singh2005 ER - TY - JOUR AU - Chautard, E. AU - Loubeau, G. AU - Tchirkov, A. AU - Chassagne, J. AU - Vermot-Desroches, C. AU - Morel, L. AU - Verrelle, P. PY - 2010 DA - 2010// TI - Akt signaling pathway: a target for radiosensitizing human malignant glioma JO - Neuro Oncol VL - 12 ID - Chautard2010 ER - TY - JOUR AU - Li, N. AU - Karin, M. PY - 1998 DA - 1998// TI - Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms JO - Proc Natl Acad Sci U S A VL - 95 UR - https://doi.org/10.1073/pnas.95.22.13012 DO - 10.1073/pnas.95.22.13012 ID - Li1998 ER - TY - JOUR AU - Khalil, S. AU - Tan, G. A. AU - Giri, D. D. AU - Zhou, X. K. AU - Howe, L. R. PY - 2012 DA - 2012// TI - Activation status of Wnt/ss-catenin signaling in normal and neoplastic breast tissues: relationship to HER2/neu expression in human and mouse JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0033421 DO - 10.1371/journal.pone.0033421 ID - Khalil2012 ER - TY - JOUR AU - Ayyanan, A. AU - Civenni, G. AU - Ciarloni, L. AU - Morel, C. AU - Mueller, N. AU - Lefort, K. AU - Mandinova, A. AU - Raffoul, W. AU - Fiche, M. AU - Dotto, G. P. AU - Brisken, C. PY - 2006 DA - 2006// TI - Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0600065103 DO - 10.1073/pnas.0600065103 ID - Ayyanan2006 ER - TY - JOUR AU - Zhang, J. AU - Li, Y. AU - Liu, Q. AU - Lu, W. AU - Bu, G. PY - 2010 DA - 2010// TI - Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2009.339 DO - 10.1038/onc.2009.339 ID - Zhang2010 ER - TY - JOUR AU - Clevers, H. PY - 2006 DA - 2006// TI - Wnt/beta-catenin signaling in development and disease JO - Cell VL - 127 UR - https://doi.org/10.1016/j.cell.2006.10.018 DO - 10.1016/j.cell.2006.10.018 ID - Clevers2006 ER - TY - JOUR AU - Tarapore, R. S. AU - Siddiqui, I. A. AU - Mukhtar, H. PY - 2012 DA - 2012// TI - Modulation of Wnt/beta-catenin signaling pathway by bioactive food components JO - Carcinogenesis VL - 33 UR - https://doi.org/10.1093/carcin/bgr305 DO - 10.1093/carcin/bgr305 ID - Tarapore2012 ER - TY - JOUR AU - Chen, H. J. AU - Hsu, L. S. AU - Shia, Y. T. AU - Lin, M. W. AU - Lin, C. M. PY - 2012 DA - 2012// TI - The beta-catenin/TCF complex as a novel target of resveratrol in the Wnt/beta-catenin signaling pathway JO - Biochem Pharmacol VL - 84 UR - https://doi.org/10.1016/j.bcp.2012.08.011 DO - 10.1016/j.bcp.2012.08.011 ID - Chen2012 ER - TY - JOUR AU - Sundram, V. AU - Chauhan, S. C. AU - Ebeling, M. AU - Jaggi, M. PY - 2012 DA - 2012// TI - Curcumin attenuates beta-catenin signaling in prostate cancer cells through activation of protein kinase D1 JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0035368 DO - 10.1371/journal.pone.0035368 ID - Sundram2012 ER - TY - JOUR AU - Ptak, C. AU - Petronis, A. PY - 2008 DA - 2008// TI - Epigenetics and complex disease: from etiology to new therapeutics JO - Annu Rev Pharmacol Toxicol VL - 48 UR - https://doi.org/10.1146/annurev.pharmtox.48.113006.094731 DO - 10.1146/annurev.pharmtox.48.113006.094731 ID - Ptak2008 ER - TY - JOUR AU - Lyko, F. AU - Brown, R. PY - 2005 DA - 2005// TI - DNA methyltransferase inhibitors and the development of epigenetic cancer therapies JO - J Natl Cancer Inst VL - 97 UR - https://doi.org/10.1093/jnci/dji311 DO - 10.1093/jnci/dji311 ID - Lyko2005 ER - TY - JOUR AU - Li, Y. AU - Tollefsbol, T. O. PY - 2010 DA - 2010// TI - Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components JO - Curr Med Chem VL - 17 UR - https://doi.org/10.2174/092986710791299966 DO - 10.2174/092986710791299966 ID - Li2010 ER - TY - JOUR AU - Mirza, S. AU - Sharma, G. AU - Parshad, R. AU - Gupta, S. D. AU - Pandya, P. AU - Ralhan, R. PY - 2013 DA - 2013// TI - Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins JO - J Breast Cancer VL - 16 UR - https://doi.org/10.4048/jbc.2013.16.1.23 DO - 10.4048/jbc.2013.16.1.23 ID - Mirza2013 ER - TY - JOUR AU - Xu, H. B. AU - Li, L. AU - Liu, G. Q. PY - 2011 DA - 2011// TI - Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines JO - Chemotherapy VL - 57 UR - https://doi.org/10.1159/000321484 DO - 10.1159/000321484 ID - Xu2011 ER - TY - JOUR AU - Xu, H. B. AU - Shen, Z. L. AU - Fu, J. AU - Xu, L. Z. PY - 2014 DA - 2014// TI - Reversal of doxorubicin resistance by guggulsterone of Commiphora mukul in vivo JO - Phytomedicine VL - 21 UR - https://doi.org/10.1016/j.phymed.2014.06.003 DO - 10.1016/j.phymed.2014.06.003 ID - Xu2014 ER - TY - STD TI - Kong JN, He Q, Wang G, Dasgupta S, Dinkins MB, Zhu G, Kim A, Spassieva S, Bieberich E. Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells. Int J Cancer. 2015;137:1610–20. ID - ref76 ER - TY - JOUR AU - Whittemore, A. S. AU - Kolonel, L. N. AU - Wu, A. H. AU - John, E. M. AU - Gallagher, R. P. AU - Howe, G. R. AU - Burch, J. D. AU - Hankin, J. AU - Dreon, D. M. AU - West, D. W. PY - 1995 DA - 1995// TI - Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada JO - J Natl Cancer Inst VL - 87 UR - https://doi.org/10.1093/jnci/87.9.652 DO - 10.1093/jnci/87.9.652 ID - Whittemore1995 ER - TY - JOUR AU - Jemal, A. AU - Siegel, R. AU - Ward, E. AU - Hao, Y. AU - Xu, J. AU - Thun, M. J. PY - 2009 DA - 2009// TI - Cancer statistics, 2009 JO - CA Cancer J Clin VL - 59 UR - https://doi.org/10.3322/caac.20006 DO - 10.3322/caac.20006 ID - Jemal2009 ER - TY - JOUR AU - Gilligan, T. AU - Kantoff, P. W. PY - 2002 DA - 2002// TI - Chemotherapy for prostate cancer JO - Urology VL - 60 UR - https://doi.org/10.1016/S0090-4295(02)01583-2 DO - 10.1016/S0090-4295(02)01583-2 ID - Gilligan2002 ER - TY - JOUR AU - Xiao, D. AU - Zeng, Y. AU - Prakash, L. AU - Badmaev, V. AU - Majeed, M. AU - Singh, S. V. PY - 2011 DA - 2011// TI - Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase JO - Mol Pharmacol VL - 79 UR - https://doi.org/10.1124/mol.110.068551 DO - 10.1124/mol.110.068551 ID - Xiao2011 ER - TY - STD TI - Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Guggulsterone for Chemoprevention of Cancer: Curr Pharm Des. 2016;22:294–306. ID - ref81 ER - TY - JOUR AU - Zu, X. Y. AU - Zhang, Q. H. AU - Liu, J. H. AU - Cao, R. X. AU - Zhong, J. AU - Yi, G. H. AU - Quan, Z. H. AU - Pizzorno, G. PY - 2012 DA - 2012// TI - ATP citrate lyase inhibitors as novel cancer therapeutic agents JO - Recent Pat Anticancer Drug Discov VL - 7 UR - https://doi.org/10.2174/157489212799972954 DO - 10.2174/157489212799972954 ID - Zu2012 ER - TY - JOUR AU - Moon, D. O. AU - Park, S. Y. AU - Choi, Y. H. AU - Ahn, J. S. AU - Kim, G. Y. PY - 2011 DA - 2011// TI - Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress JO - Biochem Pharmacol VL - 82 UR - https://doi.org/10.1016/j.bcp.2011.08.019 DO - 10.1016/j.bcp.2011.08.019 ID - Moon2011 ER - TY - JOUR AU - Hussain, A. R. AU - Uddin, S. AU - Bu, R. AU - Khan, O. S. AU - Ahmed, S. O. AU - Ahmed, M. AU - Al-Kuraya, K. S. PY - 2011 DA - 2011// TI - Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0024703 DO - 10.1371/journal.pone.0024703 ID - Hussain2011 ER - TY - JOUR AU - Shi, J. J. AU - Jia, X. L. AU - Li, M. AU - Yang, N. AU - Li, Y. P. AU - Zhang, X. AU - Gao, N. AU - Dang, S. S. PY - 2015 DA - 2015// TI - Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway JO - World J Gastroenterol VL - 21 UR - https://doi.org/10.3748/wjg.v21.i47.13277 DO - 10.3748/wjg.v21.i47.13277 ID - Shi2015 ER - TY - JOUR AU - Kim, B. H. AU - Yoon, J. H. AU - Yang, J. I. AU - Myung, S. J. AU - Lee, J. H. AU - Jung, E. U. AU - Yu, S. J. AU - Kim, Y. J. AU - Lee, H. S. AU - Kim, C. Y. PY - 2013 DA - 2013// TI - Guggulsterone attenuates activation and survival of hepatic stellate cell by inhibiting nuclear factor kappa B activation and inducing apoptosis JO - J Gastroenterol Hepatol VL - 28 UR - https://doi.org/10.1111/jgh.12314 DO - 10.1111/jgh.12314 ID - Kim2013 ER - TY - JOUR AU - Lichtman, M. A. PY - 2008 DA - 2008// TI - Battling the hematological malignancies: the 200 years' war JO - Oncologist VL - 13 UR - https://doi.org/10.1634/theoncologist.2007-0228 DO - 10.1634/theoncologist.2007-0228 ID - Lichtman2008 ER - TY - STD TI - Macha MA, Matta A, Chauhan SS, Siu KW, Ralhan R. Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells. PLoS One. 2011;6:e14728. ID - ref88 ER - TY - STD TI - Noh EM, Chung EY, Youn HJ, Jung SH, Hur H, Lee YR, Kim JS. Cis-guggulsterone inhibits the IKK/NF-kappaB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF7 breast cancer cells: guggulsterone regulates MMP9 expression in an isomer-specific manner. Int J Mol Med. 2013;31:393–99. ID - ref89 ER -