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Table 6 In vivo studies comparing PRP expression and non-heme iron availability with tannin ingestion

From: Salivary proline-rich protein may reduce tannin-iron chelation: a systematic narrative review

Study Model Intervention Study conditions Tannin concentration in challenge diet (g/kg) Fe(diet) n Study duration Measurement of bioavailability PRP measurement
[70] Sprague Dawley rats Green tea Control (acute and chronic) 28.6 g/kg green tea (nd) 20 mg/kg 6 7, 30 days % absorption (59Fe test meals), Hepatic non-heme iron SDS-PAGE, MALDI-MS/MS,DIGE
Acute gastric gavage 6 7 days
Chronic gastric gavage 6 30 days
Acute tea powder 6 7 days
Chronic tea powder 6 30 days
[37] Sprague Dawley rats Black tea Control 0.3 ± 0.0 35.9 ± 1.3 6 24 days % absorption (59Fe test meals), Hepatic non-heme iron SDS-PAGE
5% tea solids challenge tannin free diet 8.9 ± 0.5 35.9 ± 1.3 6 24 days
5% tea solids +6% gelatin challenge tannin free diet 9.9 ± 0.7 35.9 ± 1.3 6 24 days
5% tea solids chronic diet 8.9 ± 0.5a 34.3 ± 1.5 6 24 days
5% tea solids +6% gelatin chronic 9.9 ± 0.7a 34.6 ± 1.0 6 24 days
  1. aSupplied as 25 g/kg in diet
  2. SDS-PAGE sodium dodecyl polyacrylamide gel electrophoresis, MALDI-MS/MS Matrix-assisted laser desorption/ionization/mass spectrometry, DIGE difference gel electrophoresis