Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

Table 2 Correlations of plasma musclin with anthropometric parameters

Variable	Total (n = 117)		Lean (n = 44)		Overweight/obese (n = 73)
Variable	r	P	r	p	r	p
Body mass index (kg/m²)	0.327	0.001**	0.142	0.356	0.287	0.014*
Waist-to-hip ratio	−0.077	0.410	−0.050	0.746	−0.150	0.204
Systolic blood pressure (mmHg)	−0.097	0.299	−0.080	0.607	−0.167	0.157
Diastolic blood pressure (mmHg)	0.009	0.926	−0.006	0.967	−0.080	0.499
Total cholesterol (mmol/L)	−0.009	0.924	−0.202	0.188	0.044	0.709
Triglycerides (mmol/L)	0.191	0.039*	−0.019	0.903	0.237	0.044*
High-density lipoprotein (mmol/L)	−0.282	0.002**	−0.150	0.331	−0.318	0.006**
Low-density lipoprotein (mmol/L)	−0.120	0.197	−0.132	0.394	−0.156	0.189
Fasting plasma glucose (mmol/L)	−0.158	0.088	−0.174	0.258	0.314	0.007**
Fasting serum insulin (mmol/L)	0.089	0.342	−0.199	0.194	0.147	0.215
HOMA-IR (μIU x mol/L)	0.13	0.164	−0.292	0.054	0.25	0.033*
Hemoglobin A_1c (%)	0.028	0.766	−0.300	0.052	0.172	0.146

Correlations were determined using Spearman correlations
HOMA-IR homeostasis model assessment of insulin resistance. *P < 0.05, **P < 0.01