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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

Fig. 2

AMPK is associated with the phosphorylation of ACC and MCD to regulate myocardial energy metabolism. Chronic hyperglycemia activates AMPK, resulting in the phosphorylation of ACC, releasing the inhibitory effect of malonly-CoA on CPT1 and subsequently leading to enhanced entry of FFAs via CPT1 into the mitochondria for beta-oxidation. Abnormally increased beta-oxidation is further accountable for mitochondrial membrane damage through peroxyl radicals. Keys: ACC- acetyl-CoA carboxylase; AMPK- 5’ adenosine monophosphate (AMP)-activated protein kinase; CPT1- carnitine palmitoyltransferase 1; FFA- free fatty acid; MCD- malonyl-CoA decarboxylase

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Nutrition & Metabolism

ISSN: 1743-7075

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