Skip to main content
Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

Fig. 3

The role of Nrf2 in response to increased ROS within a diabetic heart. Nox and mitochondrial-ETC cause augmented production of O2 ∙−, which damages the cell through ROS. The cell reacts by activating the Nrf2-mediated antioxidant response system. Activated Nrf2 causes it to dissociate from Keap1 and migrate into the nucleus where it binds ARE and cause increased expression of cytoprotective genes and phase II detoxifying enzymes to eliminate ROS. Keys: ARE-antioxidant response element; CAT- catalase; Gpx- glutathione peroxidase; GSH- glutathione; Keap1- Kelch-like ECH-associated protein 1; Nox- NADPH oxidase; O2 ∙− superoxide ion; Nrf2- nuclear factor (erythroid-derived 2)-like 2; ROS-reactive oxygen species

Back to article page

Nutrition & Metabolism

ISSN: 1743-7075

Contact us