Table 2 Comparison of metabolites concentrations and enzyme activities based on fatty acid ratios between the three baseline states in groups 1, 2 and 3
Baseline 3 vs. Baseline 2 | Baseline 3 vs. Baseline 1 | Baseline 2 vs. Baseline 1 | |||||
|---|---|---|---|---|---|---|---|
ANOVA (p) | Tukey’s HSD (p-value) | log2 (fold change) | Tukey’s HSD (p-value) | log2 (fold change) | Tukey’s HSD (p-value) | log2 (fold change) | |
Triacylglycerols | 4.28E-02 | 9.78E-01 | 0.06 | 9.18E-02 | −0.49 | 5.95E-02 | −0.55 |
MonoetherglycerophosphocholineO_plasmenyles | 4.28E-03 | 4.70E-03 | 0.39 | 7.45E-03 | 0.08 | 3.18E-02 | −0.32 |
MonoetherglycerophosphocholineP_plasmenyles | 5.30E-03 | 1.79E-02 | 0.44 | 9.66E-01 | −0.03 | 9.35E-03 | −0.47 |
1-Monoetherglycerophosphocholine | 1.70E-03 | 3.70E-03 | 0.41 | 9.77E-01 | 0.02 | 6.55E-03 | −0.39 |
1-ether, 2-acylglycerophosphocholine O_plasmenyles | 1.50E-02 | 5.56E-01 | 0.14 | 1.34E-01 | −0.23 | 1.22E-02 | −0.37 |
1-ether, 2-acylglycerophosphocholine P_plasmenyles | 6.77E-03 | 9.07E-01 | 0.09 | 2.80E-02 | −0.46 | 9.56E-03 | −0.55 |
1-ether, 2-acylglycerophosphocholines | 7.19E-03 | 6.95E-01 | 0.12 | 5.43E-02 | −0.31 | 7.06E-03 | −0.43 |
MonoetherglycerophosphoethanolaminesP_plasmenyles | 4.18E-03 | 9.61E-02 | 0.41 | 9.65E-01 | −0.04 | 5.54E-02 | −0.46 |
Ceramides | 1.05E-03 | 9.81E-01 | −0.03 | 2.51E-03 | −0.45 | 4.29E-03 | −0.42 |
N-acyl ceramides | 3.99E-03 | 9.94E-01 | 0.01 | 1.15E-02 | −0.37 | 8.77E-03 | −0.39 |
N-acyl sphingosines | 3.99E-03 | 9.94E-01 | 0.01 | 1.15E-02 | −0.37 | 8.77E-03 | −0.39 |
Total sphingolipids | 3.03E-02 | 7.81E-01 | −0.10 | 2.95E-02 | −0.36 | 1.29E-01 | −0.26 |
Sum of Triacylglycerols& Cholesteryl Esters | 2.34E-02 | 9.94E-01 | 0.03 | 5.00E-02 | −0.49 | 3.92E-02 | −0.51 |
L-Cystine to L-Glutamate | 3.41E-02 | 9.61E-01 | −0.06 | 8.30E-02 | 0.60 | 4.58E-02 | 0.66 |
Sphingomyelinase (Cer/SM) | 2.16E-02 | 5.69E-01 | 0.09 | 1.68E-01 | −0.15 | 1.76E-02 | −0.23 |