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Table 5 Comparison of metabolites concentrations and enzyme activities based on fatty acid ratios between the final and the baseline status (Final vs. Baseline) in group 3 (meeting the NAFLD criteria at baseline but not meeting them during the follow-up)

From: Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial

Metabolites and enzyme activities Paired Student’s t-test (p-value) log2 (fold change)
Steroids 1.99E-02 −0.46
Saturated fatty acids 1.36E-02 −0.30
1-Monoacylglycerophosphocholine 2.15E-03 −0.27
2-Monoacylglycerophosphocholine 2.85E-02 −0.16
Monoacylglycerophosphocholine 1.16E-02 −0.20
Lysophosphatidylcholines 1.49E-02 −0.17
1-Monoacylglycerophosphoethanolamine 1.23E-02 −0.23
MonoetherglycerophosphoethanolaminesO_plasmanyles 2.12E-02 −0.32
Phospholipase-A2 (LPC/PC) 8.38E-03 −0.28
Phospholipase-A2 (LPE/PE) 1.91E-02 −0.21
(NEFA) n-6/n-3 1.15E-02 0.57
De novo lipogenesis (16:0/18:2n-6) 8.49E-04 −0.43
Stearoyl-CoA desaturase 1 (18:1n-9/18:0) 2.35E-04 −0.58
Elongase-6 (18:0/16:0) 6.78E-05 0.71
Delta-6- desaturase (18:3n-6/18:2n-6) 4.65E-04 −0.63
Delta-6- desaturase (18:3/18:2) 2.43E-04 −0.55
Stearoyl-CoA desaturase 1 (16:1n-7/16:0) 3.22E-03 0.11
18:1/18:0 3.65E-04 −0.21
Lecithin:cholesterolacyltransferase (ChoE/Chol) 2.64E-02 0.47
  1. log2 (fold-change) and p-values follows the criterion of heatmap figure
  2. Abbreviations: LPC lysophosphatidylcholine, LPE lysophosphatidylethanolamine, NEFA non esterified fatty acids, ChoE cholesteryl esters, Chol cholesterol