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Table 2 Odds ratios (95% confidence intervals) of type 2 diabetes associated with different levels of FGF-21 in men and women, the Singapore Chinese Health Study

From: Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women

Variables

Quartiles of FGF-21

P for trenda

Per 1 log increment

Q1

Q2

Q3

Q4

Whole dataset

 Median (range)

47 (7–75)

116 (76–157)

212 (158–288)

411 (289–1607)

  

 Cases/controls

31/64

61/63

64/62

95/62

  

 Model 1b

1.00

1.96 (1.00–3.85)

1.77 (0.94–3.33)

2.70 (1.33–5.50)

0.015

1.28 (1.03–1.59)

 Model 1b + hs-CRP

1.00

1.73 (0.87–3.44)

1.69 (0.89–3.21)

2.56 (1.24–5.31)

0.018

1.27 (1.01–1.58)

 Model 1b + TG, HDL-C

1.00

1.76 (0.85–3.67)

1.47 (0.74–2.94)

1.91 (0.87–4.20)

0.20

1.19 (0.93–1.52)

 Model 1b + ALT, GGT

1.00

1.79 (0.88–3.63)

1.77 (0.90–3.49)

2.10 (0.98–4.50)

0.09

1.20 (0.95–1.51)

 Model 2c

1.00

1.53 (0.70–3.32)

1.49 (0.72–3.10)

1.75 (0.76–4.01)

0.23

1.16 (0.90–1.50)

Men

 Median (range)

59 (7–82)

133 (83–179)

240 (180–312)

483 (317–1460)

  

 Cases/controls

16/30

32/29

32/29

37/29

  

 Model 1b

1.00

2.00 (0.76–5.28)

1.43 (0.55–3.70)

1.66 (0.53–5.21)

0.68

0.95 (0.65–1.38)

 Model 1b + hs-CRP

1.00

1.80 (0.65–4.97)

1.35 (0.51–3.55)

1.71 (0.52–5.65)

0.63

0.95 (0.64–1.41)

 Model 1b + TG, HDL-C

1.00

1.44 (0.50–4.17)

1.33 (0.47–3.83)

1.21 (0.33–4.39)

0.88

0.94 (0.60–1.46)

 Model 1b + ALT, GGT

1.00

1.66 (0.56–4.98)

1.59 (0.54–4.69)

1.27 (0.33–4.80)

0.81

0.85 (0.55–1.31)

 Model 2c

1.00

1.32 (0.36–4.80)

1.67 (0.47–5.95)

1.20 (0.24–5.94)

0.70

0.89 (0.52–1.53)e

Women

 Median (range)

30 (7–65)

107 (65–146)

197 (147–259)

375 (260–1607)

  

 Cases/controls

15/34

29/34

32/33

58/33

  

 Model 1b

1.00

2.13 (0.76–5.97)

2.15 (0.87–5.28)

4.73 (1.69–13.2)

0.004

1.60 (1.16–2.19)

 Model 1b + hs-CRP

1.00

1.74 (0.60–5.03)

2.11 (0.84–5.33)

4.07 (1.42–11.7)

0.006

1.56 (1.13–2.15)

 Model 1b + TG, HDL-C

1.00

2.28 (0.67–7.74)

1.87 (0.67–5.20)

4.37 (1.31–14.6)

0.033

1.49 (1.02–2.17)

 Model 1b + ALT, GGT

1.00

2.25 (0.72–7.03)

2.28 (0.86–6.05)

4.30 (1.38–13.4)

0.014

1.54 (1.10–2.16)

 Model 2c

1.00

1.90 (0.50–7.26)

2.28 (0.73–7.14)

4.19 (1.07–16.5)

0.036

1.53 (1.02–2.29)e

 Model 3d

1.00

1.81 (0.46–7.14)

2.27 (0.72–7.14)

3.88 (0.99–15.3)

0.047

1.50 (1.00–2.25)

  1. aLinear trend was tested by using the median level of each quartile of FGF-21
  2. bModel 1: adjusted for age at blood taken (continuous), smoking (never, ever smoker), alcohol intake (never, ever drinker), weekly moderate-to-vigorous activity (<0.5, ≥0.5 hours/week), education level (primary school and below, secondary or above), history of hypertension (yes, no), fasting status (yes, no), and body mass index (continuous)
  3. cModel 2: Model 1 plus hs–CRP (mg/L), TG (mmol/L), HDL-C (mmol/L), GGT (IU/L) and ALT (IU/L) (all in quartiles)
  4. dMode 3: Model 2 plus menopausal status (premenopausal, postmenopausal status)
  5. eThe P-interaction =0.029 between FGF-21 and sex associated with incident type 2 diabetes risk
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Nutrition & Metabolism

ISSN: 1743-7075

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