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Table 4 Odds ratios (95% confidence intervals) of type 2 diabetes by stratified analysis in men and women separately, the Singapore Chinese Health Studya

From: Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women

Variables

Per 1 log increment of FGF-21

P-interaction

Cases/ controls

OR (95% CI)

Men

 Age (year)a

   < 60

65/64

1.17 (0.74–1.86)

0.43

   ≥ 60

52/53

0.88 (0.53–1.44)

 BMIa, kg/m2

   < 23

33/67

0.94 (0.58–1.51)

0.65

  ≥ 23

84/50

1.12 (0.69–1.81)

 Physical activitya

   < 0.5 h/week

89/90

1.19 (0.81–1.74)

0.46

   ≥ 0.5 h/week

28/27

0.61 (0.26–1.44)

 Fasting statusa

  Fasting

83/85

0.98 (0.66–1.44)

0.91

  Non-fasting

34/32

1.26 (0.62–2.56)

 Hs-CRPa, mg/L

   < 1.4

51/64

1.08 (0.66–1.75)

0.79

   ≥ 1.4

66/53

1.07 (0.65–1.76)

 GGTa, IU/L

   < 30

47/68

0.81 (0.42–1.54)

0.21

   ≥ 30

70/49

1.11 (0.73–1.67)

 ALTa, IU/L

   < 26

46/70

0.83 (0.47–1.48)

0.58

   ≥ 26

71/47

1.09 (0.69–1.70)

 TGa, mmol/L

   < 1.815

49/68

0.65 (0.39–1.08)

0.61

   ≥ 1.815

68/49

1.56 (0.88–2.77)

 HDL-Ca, mmol/L

   < 0.99

75/41

1.22 (0.79–1.88)

0.95

   ≥ 0.99

42/76

0.82 (0.41–1.61)

Women

 Age (year)b

   < 60

86/86

1.48 (1.06–2.07)

0.74

   ≥ 60

48/48

1.44 (0.86–2.41)

 BMIb, kg/m2

   < 23

51/81

1.53 (1.06–2.22)

0.62

   ≥ 23

83/53

1.43 (0.95–2.14)

 Physical activityb

   < 0.5 h/week

107/104

1.62 (1.18–2.22)

0.34

   ≥ 0.5 h/week

27/30

1.29 (0.71–2.37)

 Fasting statusb

  Fasting

94/99

1.43 (1.06–1.92)

0.56

  Non-fasting

40/35

1.74 (0.86–3.53)

 Menopausal statusb

  Premenopausal

26/28

1.14 (0.61–2.12)

0.50

  Postmenopausal

108/106

1.57 (1.15–2.14)

 Hs-CRPb, mg/L

   < 1.4

51/76

1.49 (0.99–2.24)

0.67

   ≥ 1.4

83/58

1.33 (0.88–2.01)

 GGTb, IU/L

   < 30

49/78

1.34 (0.96–1.86)

0.10

   ≥ 30

85/56

1.98 (1.08–3.63)

 ALTb, IU/L

   < 20

45/80

1.36 (0.95–1.95)

0.25

   ≥ 20

89/54

2.05 (1.20–3.49)

 TGb, mmol/L

   < 1.66

48/86

1.42 (0.97–2.07)

0.52

   ≥ 1.66

86/48

1.57 (0.99–2.50)

 HDL-Cb, mmol/L

   < 1.23

83/50

1.16 (0.59–2.32)

0.69

   ≥ 1.23

51/84

1.40 (1.02–1.91)

  1. aOdds ratios were estimated after adjusting for adjusted for age at blood taken (continuous), smoking (never, ever smoker), alcohol intake (never, ever drinker), weekly moderate-to-vigorous activity (<0.5, ≥0.5 hours/week), education level (primary school and below, secondary or above), history of hypertension (yes, no), fasting status (yes, no) and BMI (continuous), except for stratifying factors
  2. bOdds ratio were adjusted for the abovementioned variables plus menopausal status
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Nutrition & Metabolism

ISSN: 1743-7075

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