Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

Table 1 General characteristics of the study participants

Characteristics	Total	Non-central obesity	Central obesity	P
N	8398	5603	2795
Male (%)	40.7	45.5	30.9	<0.001
Age (y)	52.16 ± 13.16	49.91 ± 13.23	56.69 ± 11.76	<0.001
Weight (kg)	63.26 ± 11.10	60.01 ± 9.44	69.80 ± 11.31	<0.001
WC (cm)	79.63 ± 10.16	74.67 ± 7.32	89.58 ± 7.36	<0.001
HC (cm)	93.00 ± 6.93	90.43 ± 5.45	98.17 ± 6.71	<0.001
BMI (kg/m²)	24.27 ± 3.50	22.87 ± 2.70	27.08 ± 3.22	<0.001
WHR	0.86 ± 0.09	0.83 ± 0.07	0.92 ± 0.10	<0.001
SBP (mmHg)	130.36 ± 21.48	126.27 ± 20.32	138.53 ± 21.41	<0.001
DBP (mmHg)	78.74 ± 13.09	76.67 ± 12.57	82.86 ± 13.15	<0.001
FPG (mmol/L)	5.27 (4.90,5.73)	5.20 (4.86,5.61)	5.40 (4.99,6.00)	<0.001
HbA1c (%)	5.43 ± 0.83	5.31 ± 0.74	5.67 ± 0.95	<0.001
FINS (pmol/L)	32.40 (22.80,46.30)	28.70 (20.60,40.20)	41.70 (30.20,58.40)	<0.001
HOMA-IR	1.11 (0.76,1.63)	0.97 (0.68,1.37)	1.47 (1.03,2.16)	<0.001
IR (%)	15.8	8.7	29.9	<0.001
TG (mmol/L)	1.27 (0.92,1.85)	1.14 (0.85,1.63)	1.58 (1.16,2.22)	<0.001
TC (mmol/L)	5.14 ± 1.02	5.01 ± 0.98	5.39 ± 1.04	<0.001
LDL (mmol/L)	3.07 ± 0.78	2.95 ± 0.74	3.32 ± 0.80	<0.001
HDL (mmol/L)	1.45 ± 0.31	1.49 ± 0.32	1.39 ± 0.29	<0.001
ALT (U/L)	18 (13,25)	17 (13,23)	19 (15,29)	<0.001
AST (U/L)	23 (19,28)	22 (19,27)	24 (20,29)	<0.001
ALT/AST	0.77 (0.63,0.97)	0.75 (0.61,0.94)	0.83 (0.67,1.05)	<0.001
Rural residence (%)	61.1	57.9	67.3	<0.001
Economic status (high,%)	58.4	60.4	54.5	<0.001
Current smoker (%)	21.3	22.9	18	<0.001
Alcohol consumption (%)	12.6	12	13.6	0.038

Continuous and categorical variables were expressed as the means ± standard deviation (SD) and percentages (%), respectively. Data for FPG, FINS, HOMA-IR, TG, ALT, AST and ALT/AST were skewed and were presented as medians (interquartile range). The Mann-Whitney U test and the Student t test were used for non-normally and normally distributed continuous variables, respectively, and the Pearson χ2 test was used for categorical variables
WC waist circumference, HC hip circumference, BMI body mass index, WHR waist to hip ratio, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c glycated hemoglobin, FINS fasting insulin, HOMA-IR homeostasis model assessment-insulin resistance, IR insulin resistance, TG triglycerides, TC total cholesterol, LDL low-density lipoprotein, HDL high-density lipoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase

ISSN: 1743-7075