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Table 2 mRNA levels of inflammatory and vascular markers in the adipose tissue, the liver and the aorta 3 h after the high-fat meal

From: Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat

  

VEH

INH

P

Adipose tissue

IL-1β

12 ± 2

135 ± 22

1.75389E-05

 

IL-6

0.99 ± 0.23

57 ± 22

0.0223

 

IL-10

8 ± 2

4.52 ± 1.32

0.0369

 

TNF-α

12 ± 1

45 ± 4

2.49E-09

 

PAI-1

227 ± 29

2.13 ± 0.38

0.0097

 

MCP-1

127 ± 22

24.4 ± 5.6

0.0010

 

TLR4

286 ± 24

0.87 ± 0.08

0.2915

 

TLR2

438 ± 24

8.51 ± 2.42

9.77E-06

Liver

IL-1β

40 ± 5

2.93 ± 0.25

3.75E-06

 

IL-6

0.129 ± 0.038

1.69 ± 0.36

0.1671

 

TNF-α

3.27 ± 0.30

2.98 ± 0.40

0.0002

 

PAI-1

6.63 ± 0.62

1.24 ± 0.13

0.1558

 

MCP-1

5.89 ± 0.66

2.63 ± 0.87

8.09E-05

 

TLR4

44.7 ± 3.89

0.83 ± 0.06

0.1284

 

TLR2

22.6 ± 2.2

1.76 ± 0.17

0.0010

Aorta

ICAM-1

177 ± 24

0.98 ± 0.19

0.9460

 

VCAM-1

1341 = 235

0.97 ± 0.12

0.9120

  1. Values are means ± SEMs for 9–10 rats in each group. They are expressed as arbitrary units (2-ΔCt formula using Hprt1 as the reference, with ΔCt = Ct target gene – Ct Hprt1) for the VEH group, and as fold changes for the INH group. VEH, rats treated by the vehicle; INH, rats treated by the TLR4 competitive inhibitor, Eritoran