Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

Table 1 Comparison of significantly modulated molecular and cellular functions, and transcription regulators after low-fat (LF) and high-fat (HF) meal ingestion

	LF-responsive genes	HF-responsive genes
Top 3 molecular and cellular functions
1	Cell death	Lipid metabolism
2	Cellular function and maintenance	Molecular transport
3	Carbohydrate metabolism	Small molecule biochemistry
Top 3 transcription regulators
1	FOXO1	PPARA
2	NR5A2	PPARGC1A
3	EPAS1	NR4A1

Abbreviations: EPAS1, endothelial PAS domain-containing protein 1, FOXO1 forkhead box protein O1, NR4A1 nuclear receptor subfamily 4 group A member 1, NR5A2 nuclear receptor subfamily 5 group A member 2, PPARA, peroxisome proliferator-activated receptor alpha, PPARGC1A PPAR gamma coactivator 1-alpha

ISSN: 1743-7075