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Table 1 Comparison of significantly modulated molecular and cellular functions, and transcription regulators after low-fat (LF) and high-fat (HF) meal ingestion

From: Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

  LF-responsive genes HF-responsive genes
Top 3 molecular and cellular functions
1 Cell death Lipid metabolism
2 Cellular function and maintenance Molecular transport
3 Carbohydrate metabolism Small molecule biochemistry
Top 3 transcription regulators
1 FOXO1 PPARA
2 NR5A2 PPARGC1A
3 EPAS1 NR4A1
  1. Abbreviations: EPAS1, endothelial PAS domain-containing protein 1, FOXO1 forkhead box protein O1, NR4A1 nuclear receptor subfamily 4 group A member 1, NR5A2 nuclear receptor subfamily 5 group A member 2, PPARA, peroxisome proliferator-activated receptor alpha, PPARGC1A PPAR gamma coactivator 1-alpha