Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

Table 2 Body mass and glucose metabolism during the pregestation and the gestation in dams

Data	F0-SC	F0-HF	p-value	F1-SC	F1-HF	p-value
N	5	5		5	5
Pregestational BM (g)	231.7 ± 19.2	248.8 ± 08.7	0.123	219.9 ± 16.1	246.3 ± 20.2	0.051
Pregestational FBG (mmol/L)	4.36 ± 0.49	5.80 ± 0.52^**	0.002	5.22 ± 0.58	5.08 ± 0.26	0.660
Pregestational GTT-AUC (%)	25.3 ± 2.1	33.3 ± 1.3^**	<0.001	34.6 ± 2.8	40.8 ± 4.6^*	0.032
Gestational BM (g)	371.3 ± 23.3	396.5 ± 24.7	0.127	369.6 ± 40.5	399.7 ± 21.6	0.182

BM body mass, FBG fasting blood glucose, GTT-AUC area under the curve of glucose tolerance, F0-SC standard-chow fed dams, F0-HF high-fat fed dams, F1-SC first generation born from standard-chow fed dam, F1-HF first generation born from high-fat fed dam
^**, P < 0.01 versus F0-SC

ISSN: 1743-7075