Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

Table 4 Serum glucose characteristics in F2 generation

Time	Glucose characteristics	F2-SC	F2-HF	P Value
	N	6	6
3-week-old	FBG (mmol/L)	4.6 ± 0.4	6.2 ± 0.5^**	< 0.001
	GTT-AUC	32.4 ± 1.7	41.5 ± 3.5^**	< 0.001
	Insulin(μU/ml)	5.3 ± 0.8	4.5 ± 0.1^*	0.031
	HOMA-β%	108.0 ± 47.8	34.7 ± 7.4^*	0.013
12-week-old	FBG (mmol/L)	5.3 ± 0.6	5.8 ± 0.3	0.110
	GTT-AUC	37.0 ± 1.4	40.6 ± 3.2^*	0.039
	Insulin(μU/ml)	12.1 ± 4.1	5.8 ± 0.5^*	0.013
	HOMA-β%	146.2 ± 81.9	50.8 ± 8.9^*	0.035

G fasting blood glucose, GTT-AUC area under the curve of glucose tolerance, HOMA-β homeostasis model assessment of insulin secretion index, F2-SC second generation of grandmother fed with standard-chow diet, F2-HF second generation of grandmother fed with high-fat diet
*,P < 0.05 versus F2-SC, **,P < 0.01 versus F2-SC

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