Table 5 Relative mRNA concentrations of NFE2L2 (encoding Nrf2), KEAP1 and Nrf2 target genes in the liver of rats fed diets with either soybean oil or salmon oil with various vitamin E concentrations (25, 250 or 2500 mg/kg)

NFE2L2 ^a

1.00 ± 0.40

1.02 ± 0.40

0.98 ± 0.55

1.11 ± 0.36

1.11 ± 0.47

1.06 ± 0.34

0.92

0.36

0.99

KEAP1

1.00 ± 0.33

1.10 ± 0.62

1.01 ± 0.37

1.05 ± 0.40

1.00 ± 0.53

1.00 ± 0.46

0.94

0.86

0.87

  CAT

1.00 ± 0.18

0.98 ± 0.17

1.02 ± 0.21

1.23 ± 0.25

1.02 ± 0.20

1.14 ± 0.18

0.95

0.29

0.72

  GCLM

1.00 ± 0.18

1.08 ± 0.15

1.09 ± 0.21

1.18 ± 0.17

1.14 ± 0.19

1.28 ± 0.20

0.18

0.003

0.42

  GPX1

1.00 ± 0.11

1.13 ± 0.24

1.07 ± 0.26

1.08 ± 0.20

1.13 ± 0.22

1.11 ± 0.23

0.40

0.44

0.86

  GST1A

1.00 ± 0.23

1.06 ± 0.19

1.06 ± 0.20

1.10 ± 0.23

1.15 ± 0.25

1.11 ± 0.18

0.65

0.16

0.91

  HMOX1

1.00 ± 0.29

1.07 ± 0.23

1.07 ± 0.32

1.24 ± 0.33

1.24 ± 0.52

1.12 ± 0.29

0.86

0.082

0.65

  NQO1

1.00 ± 0.20

0.94 ± 0.19

1.23 ± 0.23

1.28 ± 0.27

1.21 ± 0.16

1.50 ± 0.29

< 0.001

< 0.001

0.99

  SOD1

1.00 ± 0.31

1.18 ± 0.38

1.09 ± 0.36

1.27 ± 0.44

1.17 ± 0.45

1.01 ± 0.29

0.54

0.51

0.28

  SULT1B1

1.00 ± 0.26

1.00 ± 0.23

1.08 ± 0.18

1.11 ± 0.27

1.22 ± 0.30

1.12 ± 0.27

0.75

0.052

0.52

  UGT1A6

1.00 ± 0.41

1.11 ± 0.38

1.14 ± 0.29

1.02 ± 0.37

1.00 ± 0.24

0.98 ± 0.20

0.84

0.30

0.66