Table 3 Selected observational studies analyzing interaction of CETP gene variation with alcohol sonsumption in relation to CHD and lipid profiles
| Â | Interaction results | Â | ||||||
|---|---|---|---|---|---|---|---|---|
Author | SNPs | Phenotypes evaluated | Design | Sample | Dietary factor/Method | CHD | HDL & TG | Other lipid profiles |
Mehlig K. et al., 2014 [50] | TaqIB (rs708272) | CHD | Case control | 618 patients with CHD and 2921 controls | Alcohol consumption/ Self reported frequency of alcohol intake | Individuals with CETP TaqIB B2 homozygotes for intermediate ethanol intake had lower odds ratio than individuals with low ethanol intake (OR = 0.21; 95% CI: 0.10–0.44, Pi = 0.008). |  |  |
Corella D. et al., 2010 [35] | TaqIB (rs708272) | HDL-C TG TC LDL-C CHD | Nested case-control | N = 557 incident CHD cases and 1180 controls | Alcohol consumption/ Computerized diet history questionnaire | In drinkers, the B2B2 genotype associated with the greater risk of CHD (OR: 1.55, 95% CI: 1.05–2.29; P = 0.026), compared to non-drinkers. The greater CHD risk was reported in diabetic subjects carrying the B2 allele. | No interaction | No interaction |
Jensen M.K. et al., 2008 [49] | TaqIB (rs708272) | HDL-C TG TC LDL-C CHD | Nested case-control | N = 505 incident CHD cases and 1010 controls | Alcohol consumption/ FFQ | The OR for CHD among individuals who drank 5–14.9 g/day (modest alcohol consumption) was 1.6 (95% CI: 1.1–2.3) for B1B1 and 0.7 (95% CI: 0.6–1.0) for B2 carriers (Pi = 0.02) in reference to non-drinkers | No interaction | No interaction |