Skip to main content

Advertisement

Table 3 Inflammatory proteins secreted by human PBLs

From: Z-ligustilide and anti-inflammatory prostaglandins have common biological properties in macrophages and leukocytes

Protein Unstimulated cells 24 h) [pg/mL] Protein secretion (ratio LPS-stim./ unstim.) % inhibition by Lig (6.25 μM) % inhibition by 15d–PGJ 2 (1.25 μM)
CCL2/MCP-1 8540 0.8 87 ± 3 **) - 37 ± 34
CCL3/MIP-1α 6055 20.6 61 ± 4 *) 67 ± 36 **)
CCL4/MIP-1β 35,000 7.0 68 ± 7 **) 51 ± 14 *)
CCL5/RANTES 9225 0.8 < 2 <2
CXCL8/IL-8 20,700 21.1 <2 <2
CXCL10/IP-10 529 22.6 89 ± 3 **) 86 ± 12 **)
IFN-γ 22 10.4 84 ± 1 **) 85 ± 9 **)
TNF-α 982 24.8 46 ± 4 *) −16 ± 18
IL-1β 1055 15.5 −57 ± 5 *) 38 ± 0 *)
IL-6 11,400 8.6 −51 ± 3 **) −135 ± 32 **)
IL-12p70 12 21.1 89 ± 2 **) 85 ± 12 **)
  1. Peripheral blood leukocytes were isolated and cultured for 24 h at the indicated treatments. The proteins secreted into the culture supernatants were measured by multiparametric analysis. * p < 0.05; ** p < 0.01; *** p < 0.005 (‘LPS + substance’ treated versus ‘LPS-only’ treated cells)