From: Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study
Univariate models | Multivariate model | |||||
---|---|---|---|---|---|---|
β estimate | 95% CI for β estimate | p-value | β estimate | 95% CI for β estimate | p-value | |
Iodine intake [100 μg/day] | 0.015 | (−0.005; 0.035) | 0.136 | 0.024 | (0.004; 0.043) | 0.016 |
Gestational diabetes | ||||||
No | (ref) | (ref) | ||||
Yes | 0.093 | (0.030; 0.156) | 0.004 | 0.106 | (0.045; 0.167) | <0.001 |
Pre-eclampsia | ||||||
No | (ref) | (ref) | ||||
Yes | 0.008 | (−0.100; 0.116) | 0.883 | 0.039 | (−0.065; 0.143) | 0.460 |
Gestational hypertension | ||||||
No | (ref) | (ref) | ||||
Yes | −0.099 | (−0.153; −0.045) | <0.001 | −0.085 | (−0.138; −0.032) | 0.002 |
Gestational age [w] | 0.042 | (0.037; 0.046) | <0.001 | 0.041 | (0.036; 0.046) | <0.001 |
Stillborn | ||||||
No | (ref) | (ref) | ||||
Yes | −0.008 | (−0.097; 0.081) | 0.860 | 0.008 | (−0.076; 0.092) | 0.848 |
IVF pregnancy | ||||||
No | (ref) | (ref) | ||||
Yes | −0.116 | (−0.210; −0.023) | 0.015 | −0.126 | (−0.216; −0.037) | 0.006 |
Congenital malformations | ||||||
No | (ref) | (ref) | ||||
Yes | −0.029 | (−0.071; 0.013) | 0.179 | −0.035 | (−0.075; 0.006) | 0.095 |
Smoking | ||||||
Never | (ref) | (ref) | ||||
Past smoker | −0.012 | (−0.029; 0.005) | 0.178 | −0.012 | (−0.029; 0.005) | 0.172 |
Current smoker | −0.031 | (−0.060; −0.002) | 0.039 | −0.019 | (−0.049; 0.011) | 0.215 |
Substance abuse | ||||||
No | (ref) | (ref) | ||||
Yes | −0.029 | (−0.113; 0.056) | 0.501 | 0.000 | (−0.083; 0.083) | 0.998 |
Alcohol | ||||||
No | (ref) | (ref) | ||||
Yes | 0.015 | (−0.018; 0.048) | 0.372 | 0.016 | (−0.015; 0.046) | 0.317 |
Nutritional supplements | ||||||
No | (ref) | (ref) | ||||
Yes | −0.050 | (−0.066; −0.034) | <0.001 | −0.045 | (−0.061; −0.028) | <0.001 |
ISCO skill level - mother | ||||||
Skill level 1 | (ref) | (ref) | ||||
Skill level 2 | 0.009 | (−0.028; 0.047) | 0.634 | 0.006 | (−0.031; 0.042) | 0.764 |
Skill level 3 | 0.029 | (−0.011; 0.070) | 0.160 | 0.016 | (−0.026; 0.058) | 0.444 |
Skill level 4 | 0.039 | (0.000; 0.078) | 0.047 | 0.019 | (−0.022; 0.061) | 0.364 |
Skill level unassigned | 0.018 | (−0.111; 0.147) | 0.786 | 0.031 | (−0.093; 0.155) | 0.621 |
ISCO skill level - father | ||||||
Skill level 1 | (ref) | (ref) | ||||
Skill level 2 | 0.021 | (−0.034; 0.076) | 0.449 | 0.010 | (−0.043; 0.063) | 0.709 |
Skill level 3 | 0.037 | (−0.023; 0.097) | 0.225 | 0.007 | (−0.052; 0.067) | 0.816 |
Skill level 4 | 0.039 | (−0.016; 0.095) | 0.162 | −0.012 | (−0.069; 0.045) | 0.688 |
Skill level unassigned | −0.027 | (−0.088; 0.033) | 0.378 | −0.038 | (−0.097; 0.021) | 0.206 |
Education – mother | ||||||
Basic | (ref) | (ref) | ||||
Secondary | 0.013 | (−0.005; 0.030) | 0.164 | −0.019 | (−0.040; 0.002) | 0.081 |
University and higher | 0.030 | (0.008; 0.053) | 0.009 | −0.029 | (−0.062; 0.004) | 0.081 |
Education – father | ||||||
Basic | (ref) | (ref) | ||||
Secondary | 0.017 | (−0.003; 0.037) | 0.092 | 0.009 | (−0.014; 0.031) | 0.444 |
University and higher | 0.036 | (0.016; 0.055) | <0.001 | 0.030 | (0.000; 0.060) | 0.047 |
Equalized family intake [1000 CZK/month] | 0.009 | (−0.001; 0.019) | 0.080 | 0.005 | (−0.006; 0.016) | 0.382 |
Age - mother [y] | 0.002 | (0.000; 0.003) | 0.048 | 0.001 | (−0.001; 0.003) | 0.463 |
Height - mother [cm] | 0.003 | (0.002; 0.004) | <0.001 | 0.001 | (0.000; 0.003) | 0.059 |
Height - father [cm] | 0.002 | (0.001; 0.004) | <0.001 | 0.001 | (0.000; 0.003) | 0.028 |
Maternal preconceptional BMI [kg/m2] | −0.001 | (−0.004; 0.001) | 0.238 | −0.001 | (−0.004; 0.001) | 0.345 |
Ethnicity – mother | ||||||
European | (ref) | (ref) | ||||
Others | −0.075 | (−0.150; −0.001) | 0.048 | −0.012 | (−0.098; 0.073) | 0.780 |
Ethnicity – father | ||||||
European | (ref) | (ref) | ||||
Others | −0.037 | (−0.094; 0.020) | 0.204 | 0.011 | (−0.054; 0.075) | 0.740 |
Sex of the child | ||||||
Girl | (ref) | (ref) | ||||
Boy | 0.016 | (0.000; 0.032) | 0.051 | 0.014 | (−0.001; 0.029) | 0.076 |