Fig. 1
From: Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance
Isoform specific alterations in Hsp90 mRNA after diet-induced obesity (DIO). Male C57B/6 mice at 8 week old were fed with either a 10% kcal fat (Lean) or a 60% kcal fat high fat diet (DIO) for 12 weeks. After an 18 h fast mice were sacrificed and skeletal muscle were analyzed by quantitative real time PCR (qPCR) analysis for (a) Hsp90ab1, (b) Hsp90aa1, (c) Hsp90b1, and (b) TRAP1 mRNA. Data represents mean + standard error of the mean (SEM) of n = 5 (Lean) and n = 6 (DIO) mice. *p < 0.05, Student’s t-test