Fig. 2From: Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerancesiRNA mediated knockdown of Hsp90ab1 is isoform specific in human skeletal muscle myotubes (HSMM). HSMM were transiently transfected with siRNA targeting Hsp90ab1 (siHsp90ab1) or negative control (NC) siRNA for 48 h prior to qPCR analysis of Hsp90ab1, Hsp90aa1, Hsp90b1, TRAP1 mRNA. siRNA knockdown of Hsp90ab1 was isoform specific as mRNA expression of other Hsp90 isoforms were not affected. Data represent mean + SEM of n = 3 independent experiments. **p < 0.01 vs. NC, Student’s t-testBack to article page