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Table 4 Meta-analysis of the FOS supplementation effect on fasting blood glucose and insulin concentrations in rodents

From: Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

Parameter Metabolic health or diet Treatment N Mean ± SEM Minimum value Maximum value P-value Treatment
Fasting blood glucose, mmol/l Healthy + unhealthy Control 15 10.6 ± 1.6 4.8 25.2 0.0124
FOS 17 8.7 ± 1.3 4.6 26.3
Healthy Control 7 6.8 ± 0.4 4.8 8.3 0.002
FOS 9 6.1 ± 0.4 4.6 8.1
Unhealthy (obese or diabetic) Control 8 13.9 ± 2.6 5.5 25.2 0.0398
FOS 8 11.5 ± 2.5 4.7 26.3
Low-fat (< 20%E) Control 7 8.9 ± 2.7 4.8 25.2 0.0083
FOS 9 8.0 ± 2.3 4.6 26.3
High-fat (> 20%E) Control 8 12.0 ± 1.9 5.7 18.3 0.0225
FOS 8 9.4 ± 1.3 4.7 13.4
Fasting blood insulin, pmol/l Healthy + unhealthy Control 6 155.3 ± 29.4 73.7 253 0.0936
FOS 8 116.1 ± 23.8 52.6 225
Healthy Control 5 135.8 ± 26.9 73.7 214.8 0.5922
FOS 7 122.6 ± 26.5 52.6 225
Unhealthy (obese or diabetic) Control 1 253.0
FOS 1 70.6  
Low-fat (< 20%E) Control 3 160.1 ± 50.9 77.4 253 0.0136
FOS 5 74.4 ± 10.1 52.6 110
High-fat (>  20%E)a Control 3 150.5 ± 41.2 73.7 214.8 0.2159
FOS 3 185.7 ± 32.8 120.5 225
  1. E energy, FOS fructo-oligosaccharides
  2. aOnly on healthy animals (not enough data on unhealthy animals)