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Table 1 Statistical analysis results of the main metabolite change in urine

From: Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats

Metabolites Group HFD vs CD Group LF vs HFD
p value† Adjust p value‡ Trend p value† Adjust p value‡ Trend
Acetoacetate < 0.0001 < 0.0001 ↑** 0.0085 0.00173 ↓**
Creatine < 0.0001 < 0.0001 ↑**    
Creatinine < 0.0001 < 0.0001 ↑**    
Allantoin < 0.0001 0.0002 ↑**    
Phenylacetate 0.0022 0.0030 ↑**    
Hippurate < 0.0001 0.0002 ↑** < 0.0001 < 0.0001 ↑**
Phenylalanine 0.0023 0.0029 ↑**    
Succinimide < 0.0001 0.0002 ↑**    
N-Acetylglutamate 0.0001 0.0003 ↑**    
Uracil 0.0003 0.0006 ↑**    
Valine < 0.0001 < 0.0001 ↑**    
Levulinate 0.0008 0.0012 ↑**    
Alanine 0.0020 0.0030 ↑**    
2-Methylglutarate 0.0002 0.0004 ↑**    
p-cresol 0.0005 0.0008 ↑**    
Leucine 0.0021 0.0029 ↑**    
Trimethylamine 0.0027 0.0032 ↑**    
2-Hydroxybutyrate 0.0132 0.0146 ↑*    
Glycogen 0.0025 0.0031 ↑**    
Phenylacetylglycine 0.0373 0.0383 ↑*    
Dimethylamine 0.0024 0.0030 ↑**    
Carnitine < 0.0001 < 0.0001 ↑**    
Taurine 0.0001 0.0003 ↑**    
Tryptophan < 0.0001 < 0.0001 ↑**    
2PY < 0.0001 < 0.0001 ↑**    
Guanine 0.0004 0.0007 ↑**    
Nicotinamide 0.0068 0.0083 ↑**    
Histidine 0.0160 0.0172 ↑* 0.0283 0.0367 ↓*
Phosphorylcholine 0.0318 0.0344 ↓*    
Ornithine 0.0097 0.0111 ↓**    
N-Nitrosodimethylamine 0.0324 0.0341 ↓* 0.0371 0.0402 ↑*
Glycerol 0.0021 0.0029 ↓** 0.0003 0.0018 ↑**
Citrate 0.0398 0.0398 ↓*    
Betaine 0.0004 0.0007 ↓**    
Sucrose 0.0005 0.0008 ↓**    
Glycine < 0.0001 < 0.0001 ↓**    
Glycerophosphocholine < 0.0001 < 0.0001 ↓**    
Propylene glycol < 0.0001 < 0.0001 ↓**    
Galactonate < 0.0001 < 0.0001 ↓**    
Pseudouridine < 0.0001 0.0002 ↓**    
Fumarate 0.0002 0.0004 ↓**    
4PY     0.0005 0.0015 ↑**
Ethanol     0.0011 0.0029 ↑**
N-Methylhydantoin     0.0175 0.0285 ↑*
Sarcosine     0.0025 0.0055 ↑**
Xanthine     0.0291 0.0344 ↑*
Acetamide     0.0243 0.0351 ↓*
Pyruvate     0.0133 0.0246 ↓*
Formate     0.0408 0.0408 ↓*
Trimethylamine N-oxide     0.0003 0.0013 ↓**
  1. Abbreviations: 2PY N′-methyl-2-pyridone-5-carboxamide, 4PY N′-methyl-4-pyridone-3-carboxamide
  2. †From Student t test. *p < 0.05; **p < 0.01. ‡Adjusted by false discovery rate method across the metabolites within each comparison. HFD vs CD: compare HFD to CD; LF vs HFD: compare LF to HFD