Parameters | Control rats | ZDF rats | IIV (%) |
---|
Estimated value | RSE (%) | Estimated value | RSE (%) |
---|
K
CM
(hr
− 1
)
| 0.13 | 16.8 | 0.13 | 16.8 | – |
K
MC
(hr
−1
)
| 0.0629 | – | 0.0629 | – | – |
K
MS
(hr
−1
)
| 0.605 | 9.5 | 0.605 | 9.5 | – |
K
SS
(hr
−1
)
| 3220 | – | 3220 | – | – |
K
EL
(hr
−1
)
| 0.245 | – | 0.245 | – | – |
Vc (L/kg)
| 0.15 | – | 0.15 | – | – |
K
SH
(hr
−1
)
| 11.6 | 20.5 | 13.5 | 106.6 | – |
K
HM
(hr
−1
)
| 30.7 | 31.1 | 2.54 | 14.7 | 70.1 |
K
HC
(hr
−1
)
| 11.1 | 4.8 | 0.52 | 668.9 | – |
K
HP
(hr
−1
)
| 142 | 18.5 | 20.4 | 29.7 | 45.4 |
K
PH
(hr
−1
)
| 5.13 | 10.4 | 0.032 | 16.0 | – |
- ZDF zucker diabetic fatty, IIV inter-individual variability, RSE relative standard error, K
CM
& K
MC
inter-compartment rate constant between peripheral and methionine compartment, K
MS
rate constant from methionine to S-adenosylmethionine, K
SS
rate constant from S-adenosylmethionine to S-adenosyl homocysteine, K
EL
elimination rate constant, Vc apparent volume of distribution of peripheral compartment, K
SH
rate constant from S-adenosylhomocysteine to homocysteine, K
HM
rate constant from homocysteine to methionine, K
HC
rate constant from homocysteine to cysteine, K
HP
& K
PH
inter-compartment rate constant between homocysteine and peripheral compartment