Skip to main content

Table 1 Final estimated MMC model parameters

From: Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet

Parameters

Control rats

ZDF rats

IIV (%)

Estimated value

RSE (%)

Estimated value

RSE (%)

K CM (hr − 1 )

0.13

16.8

0.13

16.8

–

K MC (hr −1 )

0.0629

–

0.0629

–

–

K MS (hr −1 )

0.605

9.5

0.605

9.5

–

K SS (hr −1 )

3220

–

3220

–

–

K EL (hr −1 )

0.245

–

0.245

–

–

Vc (L/kg)

0.15

–

0.15

–

–

K SH (hr −1 )

11.6

20.5

13.5

106.6

–

K HM (hr −1 )

30.7

31.1

2.54

14.7

70.1

K HC (hr −1 )

11.1

4.8

0.52

668.9

–

K HP (hr −1 )

142

18.5

20.4

29.7

45.4

K PH (hr −1 )

5.13

10.4

0.032

16.0

–

  1. ZDF zucker diabetic fatty, IIV inter-individual variability, RSE relative standard error, K CM & K MC inter-compartment rate constant between peripheral and methionine compartment, K MS rate constant from methionine to S-adenosylmethionine, K SS rate constant from S-adenosylmethionine to S-adenosyl homocysteine, K EL elimination rate constant, Vc apparent volume of distribution of peripheral compartment, K SH rate constant from S-adenosylhomocysteine to homocysteine, K HM rate constant from homocysteine to methionine, K HC rate constant from homocysteine to cysteine, K HP & K PH inter-compartment rate constant between homocysteine and peripheral compartment