|
Parameters
|
Control rats
|
ZDF rats
|
IIV (%)
|
|---|
|
Estimated value
|
RSE (%)
|
Estimated value
|
RSE (%)
|
|---|
|
K
CM
(hr
− 1
)
|
0.13
|
16.8
|
0.13
|
16.8
|
–
|
|
K
MC
(hr
−1
)
|
0.0629
|
–
|
0.0629
|
–
|
–
|
|
K
MS
(hr
−1
)
|
0.605
|
9.5
|
0.605
|
9.5
|
–
|
|
K
SS
(hr
−1
)
|
3220
|
–
|
3220
|
–
|
–
|
|
K
EL
(hr
−1
)
|
0.245
|
–
|
0.245
|
–
|
–
|
|
Vc (L/kg)
|
0.15
|
–
|
0.15
|
–
|
–
|
|
K
SH
(hr
−1
)
|
11.6
|
20.5
|
13.5
|
106.6
|
–
|
|
K
HM
(hr
−1
)
|
30.7
|
31.1
|
2.54
|
14.7
|
70.1
|
|
K
HC
(hr
−1
)
|
11.1
|
4.8
|
0.52
|
668.9
|
–
|
|
K
HP
(hr
−1
)
|
142
|
18.5
|
20.4
|
29.7
|
45.4
|
|
K
PH
(hr
−1
)
|
5.13
|
10.4
|
0.032
|
16.0
|
–
|
- ZDF zucker diabetic fatty, IIV inter-individual variability, RSE relative standard error, K
CM
& K
MC
inter-compartment rate constant between peripheral and methionine compartment, K
MS
rate constant from methionine to S-adenosylmethionine, K
SS
rate constant from S-adenosylmethionine to S-adenosyl homocysteine, K
EL
elimination rate constant, Vc apparent volume of distribution of peripheral compartment, K
SH
rate constant from S-adenosylhomocysteine to homocysteine, K
HM
rate constant from homocysteine to methionine, K
HC
rate constant from homocysteine to cysteine, K
HP
& K
PH
inter-compartment rate constant between homocysteine and peripheral compartment
