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Table 1 Final estimated MMC model parameters

From: Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet

Parameters Control rats ZDF rats IIV (%)
Estimated value RSE (%) Estimated value RSE (%)
K CM (hr − 1 ) 0.13 16.8 0.13 16.8
K MC (hr −1 ) 0.0629 0.0629
K MS (hr −1 ) 0.605 9.5 0.605 9.5
K SS (hr −1 ) 3220 3220
K EL (hr −1 ) 0.245 0.245
Vc (L/kg) 0.15 0.15
K SH (hr −1 ) 11.6 20.5 13.5 106.6
K HM (hr −1 ) 30.7 31.1 2.54 14.7 70.1
K HC (hr −1 ) 11.1 4.8 0.52 668.9
K HP (hr −1 ) 142 18.5 20.4 29.7 45.4
K PH (hr −1 ) 5.13 10.4 0.032 16.0
  1. ZDF zucker diabetic fatty, IIV inter-individual variability, RSE relative standard error, K CM & K MC inter-compartment rate constant between peripheral and methionine compartment, K MS rate constant from methionine to S-adenosylmethionine, K SS rate constant from S-adenosylmethionine to S-adenosyl homocysteine, K EL elimination rate constant, Vc apparent volume of distribution of peripheral compartment, K SH rate constant from S-adenosylhomocysteine to homocysteine, K HM rate constant from homocysteine to methionine, K HC rate constant from homocysteine to cysteine, K HP & K PH inter-compartment rate constant between homocysteine and peripheral compartment