Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet

Table 1 Final estimated MMC model parameters

Parameters	Control rats		ZDF rats		IIV (%)
Parameters	Estimated value	RSE (%)	Estimated value	RSE (%)	IIV (%)
K _CM (hr ^− 1 )	0.13	16.8	0.13	16.8	–
K _MC (hr ⁻¹ )	0.0629	–	0.0629	–	–
K _MS (hr ⁻¹ )	0.605	9.5	0.605	9.5	–
K _SS (hr ⁻¹ )	3220	–	3220	–	–
K _EL (hr ⁻¹ )	0.245	–	0.245	–	–
Vc (L/kg)	0.15	–	0.15	–	–
K _SH (hr ⁻¹ )	11.6	20.5	13.5	106.6	–
K _HM (hr ⁻¹ )	30.7	31.1	2.54	14.7	70.1
K _HC (hr ⁻¹ )	11.1	4.8	0.52	668.9	–
K _HP (hr ⁻¹ )	142	18.5	20.4	29.7	45.4
K _PH (hr ⁻¹ )	5.13	10.4	0.032	16.0	–

ZDF zucker diabetic fatty, IIV inter-individual variability, RSE relative standard error, K_CM & K_MC inter-compartment rate constant between peripheral and methionine compartment, K_MS rate constant from methionine to S-adenosylmethionine, K_SS rate constant from S-adenosylmethionine to S-adenosyl homocysteine, K_EL elimination rate constant, V_c apparent volume of distribution of peripheral compartment, K_SH rate constant from S-adenosylhomocysteine to homocysteine, K_HM rate constant from homocysteine to methionine, K_HC rate constant from homocysteine to cysteine, K_HP & K_PH inter-compartment rate constant between homocysteine and peripheral compartment