|
MnSOD Val16Ala (rs4880)
|
OR (95% CI) quartiles
|
P for trend
|
P for interaction
|
|---|
|
Q1
|
Q2
|
Q3
|
Q4
|
|---|
|
Genotype
|
|
Val/Val (n = 142)
|
1 (ref.)
|
1.79 (0.66–4.83)
|
2.02 (0.71–5.72)
|
0.97 (0.36–2.6)
|
0.055
|
0.082
|
|
Ala/Val (n = 319)
|
2.33 (1.18–4.59)
|
3.48 (1.83–6.63)
|
6.38 (3.33–13.2)
|
4.47 (2.64–7.58)
|
0.063
|
|
Ala/Ala (n = 61)
|
1.58 (0.33–7.55)
|
4.75 (0.99–22.67)
|
4.75 (0.91–24.55)
|
1.78 (1.06–2.99)
|
0.133
|
|
Dominant Model
|
|
Val/Val (n = 142)
|
1 (ref.)
|
1.79 (0.66–4.83)
|
2.02 (0.71–5.72)
|
0.97 (0.36–2.6)
|
0.055
|
0.254
|
|
Ala/Ala+Ala/Val (n = 380)
|
1.98 (0.82–4.78)
|
1.13 (0.48–2.65)
|
0.66 (0.28–1.59)
|
0.3 (0.12–0.72)
|
0.002
|
- ORs (odds ratios and 95% confidence intervals) were calculated using the conditional logistic regression model, adjusted for BMI, energy intake, total Cholesterol, LDL-Cholesterol, triglyceride, Systolic and Diastolic blood pressure, smoking status and medication. The lowest quartile of serum TAC and homozygote genotype with major allele (Val/Val) were used as the reference group
