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Table 4 The PPP1R3B SNP-environment interactions on the risk of CAD and IS

From: Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population

Factor rs12785 rs330910 rs330915 rs9949
P CAD P IS P CAD P IS P CAD P IS P CAD P IS
Sex (female vs. male) 0.015 0.80 0.006 0.30 0.79 0.45 0.017 0.80
Age (≤ 60 vs. >  60 year) 0.84 0.41 0.75 0.12 0.50 0.71 0.85 0.42
BMI (≤ 24 vs. >  24 kg/m2) 0.89 0.12 0.78 0.65 0.78 0.48 0.92 0.12
Smoking (yes vs. no) 0.64 0.010 0.57 0.15 0.29 0.026 0.62 0.010
Drinking (yes vs. no) 0.61 0.92 0.41 0.41 0.62 0.87 0.57 0.96
hypertension (yes vs. no) 0.009 0.22 0.007 0.77 0.014 0.51 0.009 0.23
hyperlipidemia (yes vs. no) 0.25 0.12 0.32 0.092 0.28 0.37 0.24 0.14
  1. PCAD/PIS, the P value between patients and control, BMI body mass index. The P values for interactions of genotypes and gender, age, BMI, drinking, smoking, hypertension, hyperlipidemia on the risk of CAD/IS were obtained from unconditional logistic regression, and a P < 0.0017 was considered statistically significant after Bonferroni correction