Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population

Table 4 The PPP1R3B SNP-environment interactions on the risk of CAD and IS

Factor	rs12785		rs330910		rs330915		rs9949
Factor	P _CAD	P _IS	P _CAD	P _IS	P _CAD	P _IS	P _CAD	P _IS
Sex (female vs. male)	0.015	0.80	0.006	0.30	0.79	0.45	0.017	0.80
Age (≤ 60 vs. > 60 year)	0.84	0.41	0.75	0.12	0.50	0.71	0.85	0.42
BMI (≤ 24 vs. > 24 kg/m²)	0.89	0.12	0.78	0.65	0.78	0.48	0.92	0.12
Smoking (yes vs. no)	0.64	0.010	0.57	0.15	0.29	0.026	0.62	0.010
Drinking (yes vs. no)	0.61	0.92	0.41	0.41	0.62	0.87	0.57	0.96
hypertension (yes vs. no)	0.009	0.22	0.007	0.77	0.014	0.51	0.009	0.23
hyperlipidemia (yes vs. no)	0.25	0.12	0.32	0.092	0.28	0.37	0.24	0.14

P_CAD/P_IS, the P value between patients and control, BMI body mass index. The P values for interactions of genotypes and gender, age, BMI, drinking, smoking, hypertension, hyperlipidemia on the risk of CAD/IS were obtained from unconditional logistic regression, and a P < 0.0017 was considered statistically significant after Bonferroni correction

ISSN: 1743-7075