Table 3 Hepatic gene expression in female apolipoprotein E-deficient mice fed high-fat Western-type diets supplemented with different oils for 13 weeks

a)

CLO

Diet B [95% CI]

RWO

Diet C [95% CI]

RWO-I

Diet D [95% CI]

RWO-II

Diet E [95% CI]

CWO

Diet F [95% CI]

Tnfα

1.03 [0.24–2.59]

0.76 [0.16–2.35]

0.79 [0.11–5.21]

0.76 [0.14–2.38]

1.18 [0.16–13.9]

Mcp1

1.01 [0.37–2.70]

0.94 [0.35–2.59]

0.79 [0.11–3.15]

0.80 [0.26–2.78]

0.92 [0.23–3.27]

Il-6

1.39 [0.42–5.14]

0.87 [0.26–2.52]

1.09 [0.26–3.07]

1.18 [0.29–4.20]

0.79 [0.11–4.22]

Icam1

1.11 [0.70–1.704]

1.08 [0.65–0.21]

1.09 [0.462–2.46]

0.74 [0.02–1.87]

1.18 [0.52–2.25]

Vcam1

0.85 [0.47–1.38]

0.86 [0.55–1.31]

0.88 [0.57–1.40]

0.89 [0.50–1.29]

0.85^* [0.50–1.39]

Pon2

0.96 [0.76–1.22]

0.99 [0.76–1.29]

0.98 [0.83–1.33]

0.96 [0.81–1.12]

1.00 [0.73–1.25]

Nfe212

0.98 [0.62–1.47]

1.01 [0.64–2.04]

0.93 [0.57–1.52]

1.01 [0.65–1.48]

1.06 [0.61–1.76]

Upc2

0.96 [0.43–1.50]

1.03 [0.49–1.58]

1.03 [0.36–2.33]

1.11 [0.45–2.01]

1.35 [0.49–3.02]

Abcg5

1.15 [0.45–1.90]

1.06 [0.40–1.71]

1.08 [0.31–2.42]

1.28^* [0.51–2.22]

1.46^* [0.59–2.58]

Abcg8

1.32^* [0.64–2.61]

1.12 [0.56–2.16]

1.43^* [0.67–2.05]

1.40^* [0.65–2.66]

1.31 [0.62–2.83]

Acat2

1.00 [0.64–1-66]

1.02 [0.50–2.22]

1.02 [0.57–1.83]

1.09 [0.48–2.30]

0.91 [0.50–1.52]

Cyp7a1

0.88 [0.11–4.85]

1.19 [0.34–4.47]

1.48 [0.23–7.65]

1.95^* [0.35–8.92]

1.19 [0.37–6.34]

Hmgcr

1.16 [0.62–2.12]

1.11 [0.60–2.22]

1.12 [0.55–2.38]

1.31^* [0.62–2.67]

1.04 [0.49–2.40]

Ldlr

1.13 [0.57–2.55]

1.14 [0.61–2.09]

1.27 [0.57–2.67]

1.19 [0.61–2.38]

1.03 [0.40–2.55]

Sr-b1

1.29^* [0.76–2.29]

1.23 [0.67–2.30]

1.43^* [0.78–2.46]

1.26^* [0.58–2.25]

1.29^* [0.66–2.27]

Vldlr

0.75^* [0.34–1.59]

0.92 [0.46–1.75]

0.87 [0.23–2.05]

1.14 [0.58–2.11]

0.79 [0.30–1.61]

Pparα

1.14 [0.53–2.22]

1.41^* [0.67–2.66]

1.79^* [0.77–3.81]

1.39^* [0.74–2.77]

1.39^* [0.60–3.09]

Pparγ

0.92 [0.54–1.39]

1.15 [0.67–1.71]

1.16 [0.52–2.21]

1.26^* [0.70–2.01]

1.12 [0.47–9.86]

Fasn

1.21 [0.35–5.39]

1.01 [0.20–4.31]

0.72 [0.22–3.60]

0.94 [0.21–4.88]

0.81 [0.20–3.74]

b)

CO

Diet A [95% CI]

RWO

Diet C [95% CI]

RWO-I

Diet D [95% CI]

RWO-II

Diet E [95% CI]

CWO

Diet F [95% CI]

Tnfα

0.97 [0.39–4.10]

0.74 [0.36–1.69]

0.77 [0.15–4.35]

0.74 [0.29–1.69]

1.15 [0.25–11.0]

Mcp1

0.99 [0.37–2.70]

0.93 [0.44–2.15]

0.78 [0.09–3.45]

0.79 [0.27–2.29]

0.92 [0.22–2.73]

Il-6

0.72 [0.20–2.43]

0.63 [0.15–2.25]

0.79 [0.16–2.62]

0.85 [0.16–3.70]

0.51^* [0.07–3.67]

Icam1

0.90 [0.59–1.44]

0.98 [0.69–1.90]

0.98 [0.42–2.25]

0.67 [0.02–1.59]

1.06 [0.45–1.89]

Vcam1

1.18 [0.72–2.14]

1.01 [0.57–2.01]

1.03 [0.57–1.98]

1.05 [0.50–1.98]

1.00 [0.51–2.09]

Pon2

1.05 [0.82–1.32]

1.04 [0.77–1.39]

1.02 [0.79–1.39]

1.00 [0.78–1.26]

1.05 [0.77–1.39]

Nfe212

1.03 [0.68–1.62]

1.04 [0.74–2.14]

0.95 [0.55–1.45]

1.03 [0.73–1.40]

1.09 [0.70–1.75]

Upc2

1.04 [0.67–2.35]

1.07 [0.71–1.54]

1.07 [0.59–2.14]

1.15 [0.63–1.98]

1.41^* [0.69–2.94]

Abcg5

0.87 [0.53–2.21]

0.93 [0.57–1.47]

0.94 [0.24–2.07]

1.12 [0.64–1.89]

1.27 [0.63–2.22]

Abcg8

0.76^* [0.38–1.58]

0.85 [0.46–1.71]

1.09 [0.58–2.14]

1.06 [0.53–2.06]

0.99 [0.51–2.14]

Acat2

0.99 [0.60–1.55]

1.01 [0.48–2.13]

1.01 [0.56–1.94]

1.09 [0.45–2.46]

0.91 [0.49–1.55]

Cyp7a1

1.14 [0.21–8.90]

1.36 [0.35–9.16]

1.69 [0.23–14.4]

2.23^* [0.35–17.1]

1.36 [0.37–10.5]

Hmgcr

0.86 [0.47–1.62]

0.96 [0.62–1.63]

0.97 [0.58–1.72]

1.13 [0.60–2.18]

0.90 [0.50–2.00]

Ldlr

0.89 [0.39–1.76]

1.01 [0.49–1.78]

1.12 [0.30–2.77]

1.05 [0.49–1.98]

0.91 [0.36–2.09]

Sr-b1

0.77^* [0.44–1.32]

0.95 [0.54–1.61]

1.10 [0.65–1.74]

0.97 [0.49–1.57]

0.99 [0.54–1.59]

Vldlr

1.34^* [0.63–2.99]

1.23 [0.62–2.37]

1.17 [0.30–2.77]

1.52^* [0.76–2.97]

1.05 [0.39–2.46]

Pparα

0.88 [0.45–1.89]

1.23 [0.53–2.24]

1.57^* [0.77–3.30]

1.21 [0.76–2.97]

1.22 [0.61–2.91]

Pparγ

1.09 [0.72–1.84]

1.25^* [0.80–1.83]

1.26 [0.56–2.27]

1.37^* [0.87–2.06]

1.22 [0.59–10.6]

Fasn

0.83 [0.19–2.85]

0.84 [0.14–2.99]

0.59^* [0.19–2.66]

0.78 [0.18–3.34]

0.66 [0.15–1.27]