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Table 3 Hepatic gene expression in female apolipoprotein E-deficient mice fed high-fat Western-type diets supplemented with different oils for 13 weeks

From: Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks

a) CLO Diet B [95% CI] RWO Diet C [95% CI] RWO-I Diet D [95% CI] RWO-II Diet E [95% CI] CWO Diet F [95% CI]
Tnfα 1.03 [0.24–2.59] 0.76 [0.16–2.35] 0.79 [0.11–5.21] 0.76 [0.14–2.38] 1.18 [0.16–13.9]
Mcp1 1.01 [0.37–2.70] 0.94 [0.35–2.59] 0.79 [0.11–3.15] 0.80 [0.26–2.78] 0.92 [0.23–3.27]
Il-6 1.39 [0.42–5.14] 0.87 [0.26–2.52] 1.09 [0.26–3.07] 1.18 [0.29–4.20] 0.79 [0.11–4.22]
Icam1 1.11 [0.70–1.704] 1.08 [0.65–0.21] 1.09 [0.462–2.46] 0.74 [0.02–1.87] 1.18 [0.52–2.25]
Vcam1 0.85 [0.47–1.38] 0.86 [0.55–1.31] 0.88 [0.57–1.40] 0.89 [0.50–1.29] 0.85* [0.50–1.39]
Pon2 0.96 [0.76–1.22] 0.99 [0.76–1.29] 0.98 [0.83–1.33] 0.96 [0.81–1.12] 1.00 [0.73–1.25]
Nfe212 0.98 [0.62–1.47] 1.01 [0.64–2.04] 0.93 [0.57–1.52] 1.01 [0.65–1.48] 1.06 [0.61–1.76]
Upc2 0.96 [0.43–1.50] 1.03 [0.49–1.58] 1.03 [0.36–2.33] 1.11 [0.45–2.01] 1.35 [0.49–3.02]
Abcg5 1.15 [0.45–1.90] 1.06 [0.40–1.71] 1.08 [0.31–2.42] 1.28* [0.51–2.22] 1.46* [0.59–2.58]
Abcg8 1.32* [0.64–2.61] 1.12 [0.56–2.16] 1.43* [0.67–2.05] 1.40* [0.65–2.66] 1.31 [0.62–2.83]
Acat2 1.00 [0.64–1-66] 1.02 [0.50–2.22] 1.02 [0.57–1.83] 1.09 [0.48–2.30] 0.91 [0.50–1.52]
Cyp7a1 0.88 [0.11–4.85] 1.19 [0.34–4.47] 1.48 [0.23–7.65] 1.95* [0.35–8.92] 1.19 [0.37–6.34]
Hmgcr 1.16 [0.62–2.12] 1.11 [0.60–2.22] 1.12 [0.55–2.38] 1.31* [0.62–2.67] 1.04 [0.49–2.40]
Ldlr 1.13 [0.57–2.55] 1.14 [0.61–2.09] 1.27 [0.57–2.67] 1.19 [0.61–2.38] 1.03 [0.40–2.55]
Sr-b1 1.29* [0.76–2.29] 1.23 [0.67–2.30] 1.43* [0.78–2.46] 1.26* [0.58–2.25] 1.29* [0.66–2.27]
Vldlr 0.75* [0.34–1.59] 0.92 [0.46–1.75] 0.87 [0.23–2.05] 1.14 [0.58–2.11] 0.79 [0.30–1.61]
Pparα 1.14 [0.53–2.22] 1.41* [0.67–2.66] 1.79* [0.77–3.81] 1.39* [0.74–2.77] 1.39* [0.60–3.09]
Pparγ 0.92 [0.54–1.39] 1.15 [0.67–1.71] 1.16 [0.52–2.21] 1.26* [0.70–2.01] 1.12 [0.47–9.86]
Fasn 1.21 [0.35–5.39] 1.01 [0.20–4.31] 0.72 [0.22–3.60] 0.94 [0.21–4.88] 0.81 [0.20–3.74]
b) CO Diet A [95% CI] RWO Diet C [95% CI] RWO-I Diet D [95% CI] RWO-II Diet E [95% CI] CWO Diet F [95% CI]
Tnfα 0.97 [0.39–4.10] 0.74 [0.36–1.69] 0.77 [0.15–4.35] 0.74 [0.29–1.69] 1.15 [0.25–11.0]
Mcp1 0.99 [0.37–2.70] 0.93 [0.44–2.15] 0.78 [0.09–3.45] 0.79 [0.27–2.29] 0.92 [0.22–2.73]
Il-6 0.72 [0.20–2.43] 0.63 [0.15–2.25] 0.79 [0.16–2.62] 0.85 [0.16–3.70] 0.51* [0.07–3.67]
Icam1 0.90 [0.59–1.44] 0.98 [0.69–1.90] 0.98 [0.42–2.25] 0.67 [0.02–1.59] 1.06 [0.45–1.89]
Vcam1 1.18 [0.72–2.14] 1.01 [0.57–2.01] 1.03 [0.57–1.98] 1.05 [0.50–1.98] 1.00 [0.51–2.09]
Pon2 1.05 [0.82–1.32] 1.04 [0.77–1.39] 1.02 [0.79–1.39] 1.00 [0.78–1.26] 1.05 [0.77–1.39]
Nfe212 1.03 [0.68–1.62] 1.04 [0.74–2.14] 0.95 [0.55–1.45] 1.03 [0.73–1.40] 1.09 [0.70–1.75]
Upc2 1.04 [0.67–2.35] 1.07 [0.71–1.54] 1.07 [0.59–2.14] 1.15 [0.63–1.98] 1.41* [0.69–2.94]
Abcg5 0.87 [0.53–2.21] 0.93 [0.57–1.47] 0.94 [0.24–2.07] 1.12 [0.64–1.89] 1.27 [0.63–2.22]
Abcg8 0.76* [0.38–1.58] 0.85 [0.46–1.71] 1.09 [0.58–2.14] 1.06 [0.53–2.06] 0.99 [0.51–2.14]
Acat2 0.99 [0.60–1.55] 1.01 [0.48–2.13] 1.01 [0.56–1.94] 1.09 [0.45–2.46] 0.91 [0.49–1.55]
Cyp7a1 1.14 [0.21–8.90] 1.36 [0.35–9.16] 1.69 [0.23–14.4] 2.23* [0.35–17.1] 1.36 [0.37–10.5]
Hmgcr 0.86 [0.47–1.62] 0.96 [0.62–1.63] 0.97 [0.58–1.72] 1.13 [0.60–2.18] 0.90 [0.50–2.00]
Ldlr 0.89 [0.39–1.76] 1.01 [0.49–1.78] 1.12 [0.30–2.77] 1.05 [0.49–1.98] 0.91 [0.36–2.09]
Sr-b1 0.77* [0.44–1.32] 0.95 [0.54–1.61] 1.10 [0.65–1.74] 0.97 [0.49–1.57] 0.99 [0.54–1.59]
Vldlr 1.34* [0.63–2.99] 1.23 [0.62–2.37] 1.17 [0.30–2.77] 1.52* [0.76–2.97] 1.05 [0.39–2.46]
Pparα 0.88 [0.45–1.89] 1.23 [0.53–2.24] 1.57* [0.77–3.30] 1.21 [0.76–2.97] 1.22 [0.61–2.91]
Pparγ 1.09 [0.72–1.84] 1.25* [0.80–1.83] 1.26 [0.56–2.27] 1.37* [0.87–2.06] 1.22 [0.59–10.6]
Fasn 0.83 [0.19–2.85] 0.84 [0.14–2.99] 0.59* [0.19–2.66] 0.78 [0.18–3.34] 0.66 [0.15–1.27]
  1. Relative comparison of mice fed CO to the other diets group (a), and relative comparison of mice fed CLO to the other diets group (b). 95% confidence interval [95% CI]. The relative gene expression was analysed with REST 2009 and *denotes significant difference (p < 0.05). CO (n = 11), CLO (n = 9), RWO (n = 11), RWO-I (n = 11), RWO-II (n = 12), CWO (n = 10)