Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study

Table 2 Genotyping information of 11 GWAS-derived SNPs for WHR in 2030 Chinese children

SNP	Chr.	Position^a	Nearest gene	Allele		EAF	Call rate (%)	genotype frequencies (%, 11/12/22)			HWE P-value		EAF in Heid et al., 2010 (Ref. [6])	F _ST
SNP	Chr.	Position^a	Nearest gene	Effect (1)	Other (2)	EAF	Call rate (%)	Total sample	non-IFG	IFG	non-obese	obese	EAF in Heid et al., 2010 (Ref. [6])	F _ST
rs984222	1	119,305,366	TBX15-WARS2	G	C	0.61	99.8	37.7/46.9/15.4	39.2/45.8/15.0	28.9/53.7/17.4	0.964	0.404	0.64	< 0.01
rs1011731	1	170,613,171	DNM3-PIGC	G	A	0.13	99.9	1.7/21.9/76.4	1.6/21.0/77.4	2.8/26.7/70.5	0.588	0.938	0.43	0.11
rs4846567	1	217,817,340	LYPLAL1	G	T	0.69	99.9	46.9/43.9/9.2	47.4/43.7/8.8	43.6/45.3/11.1	0.124	0.819	0.72	< 0.01
rs10195252	2	165,221,337	GRB14	T	C	0.89	99.2	78.8/20.1/1.1	79.2/19.7/1.1	76.4/22.5/1.1	0.951	0.234	0.60	0.11
rs6795735	3	64,680,405	ADAMTS9	C	T	0.24	99.8	5.9/36.6/57.5	5.6/35.7/58.6	7.6/42.0/50.3	0.267	0.082	0.59	0.13
rs1294421	6	6,688,148	LY86	G	T	0.23	99.9	5.3/34.6/60.1	5.1/34.6/60.3	6.3/34.4/59.4	0.338	0.620	0.61	0.15
rs6905288	6	43,866,851	VEGFA	A	G	0.74	99.5	55.2/38.5/6.3	55.7/37.9/6.4	52.6/41.8/5.6	0.559	0.904	0.56	0.04
rs9491696	6	127,494,332	RSPO3	G	C	0.53	99.4	29.1/48.9/22.1	28.9/48.8/22.3	30.1/49.3/20.6	0.988	0.218	0.48	< 0.01
rs1055144	7	25,837,634	NFE2L3	T	C	0.44	99.5	19.6/48.7/31.7	19.2/48.7/32.1	22.0/48.4/29.6	0.553	0.950	0.21	0.06
rs1443512	12	52,628,951	HOXC13	A	C	0.20	98.9	4.2/30.7/65.0	4.1/30.5/65.4	4.9/32.0/63.0	0.792	0.124	0.24	< 0.01
rs4823006	22	27,781,671	ZNRF3-KREMEN1	A	G	0.49	99.4	23.9/49.4/26.7	23.0/50.2/26.8	29.4/44.4/26.2	0.910	0.442	0.57	0.01

Chr Chromosome, EAF Effect allele frequency, F_STF-statistics, HWE Hardy-Weinberg equilibrium, IFG impaired fasting glucose, SNP single nucleotide polymorphism
^aPosition: NCBI build 36.3 (NCBI, Bethesda, MD)

ISSN: 1743-7075