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Table 2 Genotyping information of 11 GWAS-derived SNPs for WHR in 2030 Chinese children

From: Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study

SNP Chr. Positiona Nearest gene Allele EAF Call rate (%) genotype frequencies (%, 11/12/22) HWE P-value EAF in Heid et al., 2010 (Ref. [6]) F ST
Effect (1) Other (2) Total sample non-IFG IFG non-obese obese
rs984222 1 119,305,366 TBX15-WARS2 G C 0.61 99.8 37.7/46.9/15.4 39.2/45.8/15.0 28.9/53.7/17.4 0.964 0.404 0.64 < 0.01
rs1011731 1 170,613,171 DNM3-PIGC G A 0.13 99.9 1.7/21.9/76.4 1.6/21.0/77.4 2.8/26.7/70.5 0.588 0.938 0.43 0.11
rs4846567 1 217,817,340 LYPLAL1 G T 0.69 99.9 46.9/43.9/9.2 47.4/43.7/8.8 43.6/45.3/11.1 0.124 0.819 0.72 < 0.01
rs10195252 2 165,221,337 GRB14 T C 0.89 99.2 78.8/20.1/1.1 79.2/19.7/1.1 76.4/22.5/1.1 0.951 0.234 0.60 0.11
rs6795735 3 64,680,405 ADAMTS9 C T 0.24 99.8 5.9/36.6/57.5 5.6/35.7/58.6 7.6/42.0/50.3 0.267 0.082 0.59 0.13
rs1294421 6 6,688,148 LY86 G T 0.23 99.9 5.3/34.6/60.1 5.1/34.6/60.3 6.3/34.4/59.4 0.338 0.620 0.61 0.15
rs6905288 6 43,866,851 VEGFA A G 0.74 99.5 55.2/38.5/6.3 55.7/37.9/6.4 52.6/41.8/5.6 0.559 0.904 0.56 0.04
rs9491696 6 127,494,332 RSPO3 G C 0.53 99.4 29.1/48.9/22.1 28.9/48.8/22.3 30.1/49.3/20.6 0.988 0.218 0.48 < 0.01
rs1055144 7 25,837,634 NFE2L3 T C 0.44 99.5 19.6/48.7/31.7 19.2/48.7/32.1 22.0/48.4/29.6 0.553 0.950 0.21 0.06
rs1443512 12 52,628,951 HOXC13 A C 0.20 98.9 4.2/30.7/65.0 4.1/30.5/65.4 4.9/32.0/63.0 0.792 0.124 0.24 < 0.01
rs4823006 22 27,781,671 ZNRF3-KREMEN1 A G 0.49 99.4 23.9/49.4/26.7 23.0/50.2/26.8 29.4/44.4/26.2 0.910 0.442 0.57 0.01
  1. Chr Chromosome, EAF Effect allele frequency, FSTF-statistics, HWE Hardy-Weinberg equilibrium, IFG impaired fasting glucose, SNP single nucleotide polymorphism
  2. aPosition: NCBI build 36.3 (NCBI, Bethesda, MD)