Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study

Table 3 Associations of the 11 SNPs with the risk of IFG in 2030 Chinese children

SNP	Nearest gene	Unadjusted for age- and sex-specific WHR-Z scores		Adjusted for age- and sex-specific WHR-Z scores
SNP	Nearest gene	OR (95% CI)	P-value	OR (95% CI)	P-value
rs984222	TBX15-WARS2	0.756 (0.624, 0.915)	0.004*	0.751 (0.620, 0.910)	0.004*
rs1011731	DNM3-PIGC	1.374 (1.058, 1.786)	0.017*	1.383 (1.063, 1.799)	0.016*
rs4846567	LYPLAL1	0.894 (0.731, 1.093)	0.276	0.895 (0.731, 1.095)	0.280
rs10195252	GRB14	0.925 (0.691, 1.239)	0.602	0.931 (0.695, 1.248)	0.633
rs6795735	ADAMTS9	1.400 (1.131, 1.734)	0.002*	1.401 (1.131, 1.735)	0.002*
rs1294421	LY86	1.054 (0.843, 1.316)	0.646	1.043 (0.835, 1.305)	0.709
rs6905288	VEGFA	0.964 (0.778, 1.195)	0.736	0.952 (0.768, 1.181)	0.657
rs9491696	RSPO3	1.107 (0.916, 1.336)	0.293	1.117 (0.925, 1.349)	0.252
rs1055144	NFE2L3	1.118 (0.926, 1.349)	0.245	1.120 (0.927, 1.352)	0.240
rs1443512	HOXC13	1.135 (0.900, 1.431)	0.284	1.121 (0.888, 1.414)	0.337
rs4823006	ZNRF3-KREMEN1	1.175 (0.973, 1.419)	0.093	1.170 (0.969, 1.413)	0.103
Unweighted GRS	–	1.059(0.989, 1.134)	0.099	1.057 (0.987, 1.132)	0.111
Weighted GRS	–	1.042 (0.975, 1.114)	0.227	1.041 (0.973, 1.113)	0.245

Logistic regression was performed to examine the independent and cumulative effects of each SNP on risk of IFG under an additive model adjusted for study group, sex, age and age squared, without or with adjustment for age- and sex-specific WHR-Z scores
CI confidence interval, GRS genetic risk score, IFG impaired fast glucose (fasting plasma glucose ≥5.6 mmol/L), OR odds ratio; SNP single nucleotide polymorphism
*Two-sided P < 0.05

ISSN: 1743-7075