Skip to main content

Advertisement

Table 3 Associations of the 11 SNPs with the risk of IFG in 2030 Chinese children

From: Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study

SNP Nearest gene Unadjusted for age- and sex-specific WHR-Z scores Adjusted for age- and sex-specific WHR-Z scores
OR (95% CI) P-value OR (95% CI) P-value
rs984222 TBX15-WARS2 0.756 (0.624, 0.915) 0.004* 0.751 (0.620, 0.910) 0.004*
rs1011731 DNM3-PIGC 1.374 (1.058, 1.786) 0.017* 1.383 (1.063, 1.799) 0.016*
rs4846567 LYPLAL1 0.894 (0.731, 1.093) 0.276 0.895 (0.731, 1.095) 0.280
rs10195252 GRB14 0.925 (0.691, 1.239) 0.602 0.931 (0.695, 1.248) 0.633
rs6795735 ADAMTS9 1.400 (1.131, 1.734) 0.002* 1.401 (1.131, 1.735) 0.002*
rs1294421 LY86 1.054 (0.843, 1.316) 0.646 1.043 (0.835, 1.305) 0.709
rs6905288 VEGFA 0.964 (0.778, 1.195) 0.736 0.952 (0.768, 1.181) 0.657
rs9491696 RSPO3 1.107 (0.916, 1.336) 0.293 1.117 (0.925, 1.349) 0.252
rs1055144 NFE2L3 1.118 (0.926, 1.349) 0.245 1.120 (0.927, 1.352) 0.240
rs1443512 HOXC13 1.135 (0.900, 1.431) 0.284 1.121 (0.888, 1.414) 0.337
rs4823006 ZNRF3-KREMEN1 1.175 (0.973, 1.419) 0.093 1.170 (0.969, 1.413) 0.103
Unweighted GRS 1.059(0.989, 1.134) 0.099 1.057 (0.987, 1.132) 0.111
Weighted GRS 1.042 (0.975, 1.114) 0.227 1.041 (0.973, 1.113) 0.245
  1. Logistic regression was performed to examine the independent and cumulative effects of each SNP on risk of IFG under an additive model adjusted for study group, sex, age and age squared, without or with adjustment for age- and sex-specific WHR-Z scores
  2. CI confidence interval, GRS genetic risk score, IFG impaired fast glucose (fasting plasma glucose ≥5.6 mmol/L), OR odds ratio; SNP single nucleotide polymorphism
  3. *Two-sided P < 0.05