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Table 4 Associations of the 11 SNPs with FPG in 2030 Chinese children

From: Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study

SNP

Nearest gene

Unadjusted for age- and sex-specific WHR-Z scores

Adjusted for age- and sex-specific WHR-Z scores

β (S.E.)

P-value

β (S.E.)

P-value

rs984222

TBX15-WARS2

−0.033 (0.016)

0.043*

− 0.032 (0.016)

0.045*

rs1011731

DNM3-PIGC

0.035 (0.024)

0.137

0.031 (0.024)

0.192

rs4846567

LYPLAL1

−0.015 (0.017)

0.390

−0.013 (0.017)

0.455

rs10195252

GRB14

0.010 (0.026)

0.704

0.011 (0.025)

0.671

rs6795735

ADAMTS9

0.033 (0.018)

0.078

0.032 (0.018)

0.083

rs1294421

LY86

0.010 (0.019)

0.597

0.011 (0.019)

0.565

rs6905288

VEGFA

−0.011 (0.018)

0.553

−0.011 (0.018)

0.545

rs9491696

RSPO3

0.020 (0.016)

0.196

0.021 (0.016)

0.174

rs1055144

NFE2L3

0.018 (0.016)

0.253

0.021 (0.016)

0.181

rs1443512

HOXC13

0.013 (0.020)

0.524

0.012 (0.020)

0.543

rs4823006

ZNRF3-KREMEN1

−0.007 (0.016)

0.677

−0.005 (0.016)

0.751

Unweighted GRS

–

0.004 (0.006)

0.464

0.005 (0.006)

0.391

Weighted GRS

–

0.004 (0.006)

0.502

0.004 (0.006)

0.418

  1. Linear regression was performed to examine the independent and cumulative effects of each SNP on FPG under an additive model adjusted for study group, sex, age and age squared, without or with adjustment for age- and sex-specific WHR-Z scores
  2. FPG fasting plasma glucose, GRSgenetic risk score, SNP single nucleotide polymorphism, S.E standard error, WHR waist-hip ratio
  3. *Two-sided P < 0.05