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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Very low-carbohydrate, high-fat, weight reduction diet decreases hepatic gene response to glucose in obese rats

Fig. 4

Effect of glucose on gene expression in rats consuming HF2 vs. VLC, LC or HC diets. Liver samples were obtained from obese rats continuing to consume an HF diet ad libitum or VLC, LC or HC diets in restricted amounts for 8 weeks (Phase 2); feed-deprived 16h (dark bars) and 3 h post-glucose (light bars). Relative hepatic gene expression is plotted as 2-dCt. Means ± SEM are shown; labelled means, for a given gene and condition, without a common letter differ from each other, p < 0.05. *Different from Feed-deprived, p< 0.05. Ct ranges across all groups and conditions are shown in Parentheses; Acaca: acetyl-CoA carboxylase (28–32); Cpt1a: carnitine Palmitoyl transferase-1a (24–27); Fasn: fatty acid synthase (25–32); Gck: glucokinase (24–30); Insig2: insulin signaling protein-2 (24–27); Pck1: phosphoenolpyruvate carboxykinase-1 (21–27); Scd1: stearoyl-CoA desaturase-1 (24–32); Srebf1: Sterol regulatory element-binding protein(25–29); Rplp2:Ribosomal protein P2 (24–25); HF2, high-fat Phase 2; VLC, very low-carbohydrate; LC, low-carbohydrate; HC, high-carbohydrate

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