Very low-carbohydrate, high-fat, weight reduction diet decreases hepatic gene response to glucose in obese rats

Nutrition & Metabolism

Table 2 Effects of diet on body composition in male rats¹

DIET	Body	Visceral	Total	Body	Liver	Muscle	Leptin
DIET	Weight (g)	Fat (g)	Fat (g)	Fat (%)	Lipid (mg/g)	TG (mg/g)	ng/mL
Phase 1
LF	558 ± 24^b	39 ± 5.1^b	67.2 ± 8.3^c	11.3 ± 1.2^b	49.9 ± 5.8^c	5.9 ± 1.7^bcd	11.6 ± 2.1^b
HF1	665 ± 32^a	69.0 ± 11.1^a	130 ± 17.3^ab	19.1 ± 1.9^a	73 ± 5.2^a	8.1 ± 0.4^ab	42.6 ± 8.2^a
Phase 2
HF2	748 ± 13^a	78.2 ± 7.2^a	148 ± 9.6^a	19.7 ± 1.0^a	72.1 ± 6.9^a	9.5 ± 0.7^a	38.9 ± 5.9^a
VLC	628 ± 14^b	51.1 ± 3.7^ab	92.9 ± 7.8^bc	14.7 ± 1^ab	52.5 ± 6^bc	6.9 ± 1.4^bc	14.1 ± 2.2^b
LC	613 ± 0.9^b	42.2 ± 3.6^b	75.6 ± 5.4^c	12.3 ± 0.8^b	67.8 ± 4.9^ab	5.5 ± 0.7^cd	8.7 ± 1.1^b
HC	610 ± 11^b	37.9 ± 2.5^b	72.5 ± 6.1^c	11.9 ± 1^b	53 ± 6.9^bc	4.5 ± 0.7^cd	7.9 ± 1.0^b
Phase 3
VC3	632 ± 10^b				60.8 ± 4.2^bc	3.4 ± 0.1^e	8.6 ± 1.8^b
VC7	644 ± 11^b				54.1 ± 3.5^bc	4.9 ± 1.1^cd	7.4 ± 1.4^b

¹Values are means ± SEM. Labeled means in a column without a common letter differ, P < 0.05; the letter a represents the highest value .HOMA-IR units are (mmol/L)(μU/mL)/22.5. LF, lower-fat; HF1, high-fat Phase 1; HF2, high-fat Phase 2; VLC, very low-carbohydrate; LC, low-carbohydrate; HC, high-carbohydrate

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