Table 2 Changes in lysophospholipids concentration (μM) categorized by changes in waist circumference and Weight loss
From: Changes in lysophospholipids and liver status after weight loss: the RESMENA study
All subjects (n = 33) | Δ Waist circumference (cm) | Δ Weight (kg) | |||||
|---|---|---|---|---|---|---|---|
Δ LP | Baseline | 6 months | p-value | < P50 | ≥ P50 | < P50 | ≥ P50 |
LPC 14:0 | 1.7 (0.1) | 1.2 (0.1) | 0.008 | 0.5 (1) | 1.1 (1) | 0.8 (1) | 0.8 (1) |
LPC 15:0 | 0.8 (0.05) | 0.7 (0.04) | 0.024 | 0.3 (0.5) | 0.7 (0.4)* | 0.4 (0.6) | 0.6 (0.4) |
LPC 16:0 | 147 (6) | 136 (8) | 0.231 | 83.2 (101) | 158.0 (75)** | 108.1 (67) | 137.9 (112) |
LPC 16:1 | 3.7 (0.2) | 3 (0.19) | 0.009 | 1.1 (2.4) | 8.3 (1)* | 2.1 (2) | 2.4 (2) |
LPC 17:0 | 3 (0.2) | 2.6 (0.2) | 0.105 | 1.1 (2) | 3.1 (1)* | 1.8 (2) | 2.5 (2) |
LPC 17:1 | 0.6 (0) | 0.5 (0) | 0.095 | 0.3 (0.4) | 0.5 (0.2) | 0.4 (0.4) | 0.4 (0.3) |
LPC 18:0 | 78.6 (4.8) | 65.5 (5) | 0.060 | 29.0 (66) | 74.3 (51)* | 37.2 (57) | 66.6 (65) |
LPC 18:1 | 55.8 (4.1) | 49.8 (3.3) | 0.189 | 24.9 (32) | 61.6 (43)* | 49.5 (34) | 51.0 (48) |
LPC 18:2 | 56.8 (3.2) | 57 (4) | 0.856 | 47.7 (48) | 68.1 (43) | 49.5 (34) | 66.6 (54 |
LPC 18:3 | 81.4 (3.7) | 77.4 (5.3) | 0.503 | 50.0 (63) | 92.6 (50)* | 66.2 (38) | 79.3 (72) |
LPC 18:4 | 1.1 (0.06) | 0.89 (0.05) | 0.006 | 0.3 (0.6) | 0.9 (0.4)* | 0.6 (0.6) | 0.7 (0.6) |
LPC 20:0 | 0.31 (0.02) | 0.29 (0.02) | 0.547 | 0.2 (0.3) | 0.2 (0.2) | 0.3 (0.2) | 0.2 (0.2) |
LPC 20:1 | 0.84 (0.06) | 0.74 (0.04) | 0.124 | 0.4 (0.5) | 0.8 (0.4)* | 0.5 (0.4) | 0.7 (0.5) |
LPC 20:2 | 0.83 (0.06) | 0.7 (0.04) | 0.090 | 0.3 (0.6) | 0.8 (0.3)* | 0.4 (0.6) | 0.6 (0.5) |
LPC 20:3 | 9.94 (0.6) | 8.77 (0.56) | 0.214 | 6.0 (9) | 9.0 (6) | 7.2 (7) | 7.8 (8) |
LPC 20:4 | 36.5 (2) | 31 (1.7) | 0.026 | 16.2 (16) | 34.5 (18)* | 21.2 (17) | 30.2 (21) |
LPC 22:4 | 0.43 (0.02) | 0.39 (0.02) | 0.222 | 0.2 (0.3) | 0.4 (0.2) | 0.3 (0.3) | 0.3 0.2) |
LPC 22:5 | 1 (0.07) | 0.98 (0.05) | 0.256 | 0.7 (0.8) | 0.9 (0.7) | 0.8 (0.7) | 0.8 (0.7) |
LPC 22:6 | 7.8 (0.5) | 6.6 (0.5) | 0.093 | 0.7 (0.8) | 0.9 (0.7) | 0.9 (0.8) | 0.8 (0.9) |
LPE 18:0 | 25.7 (1.7) | 23 (1.5) | 0.230 | 15.1 (20) | 24.9 (17) | 20.6 (19) | 20.0 (20) |
LPE 18:1 | 3.8 (0.36) | 3.57 (0.3) | 0.627 | 3.1 (4) | 3.5 (4) | 3.5 (4) | 3.1 (5) |
LPE 18:2 | 4.1 (0.3) | 3.9 (0.4) | 0.803 | 4.2 (6) | 3.4 (4) | 4.0 (5) | 3.6 (5.0) |
LPE 20:0 | 6.7 (0.58) | 5.7 (0.49) | 0.202 | 3.3 (6) | 6.1 (5) | 4.9 (5) | 4.8 (6) |
LPE 20:2 | 5.2 (0.39) | 5.1 (0.4) | 0.911 | 4.4 (5.5) | 5.7 (5) | 4.7 (5) | 5.4 (5) |
LPE 20:3 | 0.43 (0.01) | 0.42 (0.01) | 0.872 | 0.4 (0.2) | 3.0 (2) | 0.4 (0.2) | 0.4 (0.2) |
LPE 20:4 | 3.37 (0.16) | 3.15 (0.21) | 0.427 | 2.8 (3.1) | 0.2 (0.8) | 3.1 (2) | 2.7 (2) |
LPE 20:5 | 0.75 (0.06) | 0.77 (0.16) | 0.917 | 1.3 (2.4) | 0.5 (0.2) | 1.1 (2) | 0.4 (0.9) |
LPE 22:4 | 0.46 (0.01) | 0.48 (0.02) | 0.332 | 0.4 (0.2) | 0.5 (0.2) | 0.4 (0.2) | 0.5 (0.3) |
LPE 22:5 | 0.27 (0.0) | 0.27 (0.0) | 0.931 | 0.2 (0.1) | 0.2 (0.09) | 0.2 (0.09) | 0.2 (0.1) |
LPE 22:6 | 1.9 (0.13) | 1.66 (0.1) | 0.054 | 1.05 (1) | 1.6 (0.9) | 1.5 (1) | 1.1 (1) |
LPI 18:0 | 2.5 (0.2) | 2.2 (0.23) | 0.367 | 1.2 (3) | 2.5 (2) | 1.7 (3) | 2.1 (2) |
LPI 18:1 | 0.61 (0.06) | 0.5 (0.03) | 0.105 | 0.3 (0.5) | 0.4 (0.4) | 0.4 (0.4) | 0.3 (0.5) |
Scores of lysophospholipids | |||||||
∑LPC-s | 2.5 (14) | −5.4 (13)* | 0.027 | 0.1 (0.5) | −0.8 (1)* | −0.5 (0.1) | −0.1 (0.8) |
∑LPE-s | 0.5 (7) | −0.8 (8) | 0.495 | −0.2 (1) | −0.2 (1) | −0.1 (1) | −0.03 (1) |
∑LPI-s | 0.2 (1) | −0.3 (1) | 0.178 | −0.65 (1) | −0.03 (1) | − 0.4 (1) | −0.2 (1) |
∑LPstotal | 2.6 (19) | −9.2 (20)* | 0.024 | −0.07 (0.5) | −0.6 (0.8)* | − 0.2 (0.6) | −0.5 (0.8) |