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Table 3 Generalized linear models of the effects of the PPARG2 Pro12Ala polymorphism on the body composition of severely obese individuals after a 12-week nutritional intervention

From: PPARG2 Pro12Ala polymorphism influences body composition changes in severely obese patients consuming extra virgin olive oil: a randomized clinical trial

Variables Weight change Percentage body fat change Fat free mass change Lean mass change
Adj. β* 95% CI P Adj. β* 95% CI P Adj. β* 95% CI P Adj. β* 95% CI P
Intercept 3.504 −4.216, 11.224 0.374 0.432 −3.895, 9.115 0.432 −3.597 −11.462, 4.268 0.370 −3.593 −11.783, 4.597 0.390
Age 0.031 − 0.063, 0.125 0.517 − 0.056 − 0.125, 0.012 0.105 0.067 − 0.015, 0.193 0.110 0.071 −0.015, 0.157 0.107
Gender
 Females 0 Reference   0 Reference   0 Reference   0 Reference  
 Males −2.354 −4.741, 0.034 0.053 −0.010 − 2.450, 2.429 0.993 1.105 −1.844, 4.054 0.463 1121 − 1.950, 4.192 0.474
Baseline BMI −0.060 −0.198, 0.078 0.397 0.006 −0.138, 0.150 0.938 0.019 −0.155, 0.193 0.827 0.015 −0.166, 0.197 0.868
Sedentary time change 0.007 −0.006, 0.020 0.270 0.002 −0.007, 0.011 0.610 0.001 −0.010, 0.012 0.876 0.001 −0.010, 0.012 0.856
Nutritional intervention
 OO 0 Reference   0 Reference   0 Reference   0 Reference  
 DieTBra −5.001 −7.135, −2.867 < 0.001 0.110 −1.430, 1.650 0.889 −1.390 −3.252, 0.472 0.143 −1.510 −3.448, 0.429 0.127
 DieTBra+OO −4.397 −6.474, −2.321 < 0.001 0.001 −1.468, 1.468 1.000 −1.502 −3.277, 0.273 0.097 −1.574 −3.423, 0.274 0.095
Pro12Ala polymorphism
 ProPro 0 Reference   0 Reference   0 Reference   0 Reference  
 12Ala carriers 0.508 −1.823, 2.839 0.669 −2.338 −4.067, −0.608 0.008 2.917 0.825, 5.008 0.006 3.122 0.945, 5.301 0.005
  1. Dependent variables: 12thweek measurement – baseline measurement. OO olive oil group, DieTBra traditional Brazilian diet group, DieTBra + OO traditional Brazilian diet plus olive oil group, BMI Body Mass Index
  2. *General linear models were adjusted for age, gender, baseline BMI and change in sedentary time. When interactions were tested (SNP x nutritional intervention, gender x nutritional intervention), the P value was not significant (P > 0.05). Data for the outcome fat mass was not significant