PPARG2 Pro12Ala polymorphism influences body composition changes in severely obese patients consuming extra virgin olive oil: a randomized clinical trial

Table 3 Generalized linear models of the effects of the PPARG2 Pro12Ala polymorphism on the body composition of severely obese individuals after a 12-week nutritional intervention

Variables	Weight change			Percentage body fat change			Fat free mass change			Lean mass change
Variables	Adj. β*	95% CI	P	Adj. β*	95% CI	P	Adj. β*	95% CI	P	Adj. β*	95% CI	P
Intercept	3.504	−4.216, 11.224	0.374	0.432	−3.895, 9.115	0.432	−3.597	−11.462, 4.268	0.370	−3.593	−11.783, 4.597	0.390
Age	0.031	− 0.063, 0.125	0.517	− 0.056	− 0.125, 0.012	0.105	0.067	− 0.015, 0.193	0.110	0.071	−0.015, 0.157	0.107
Gender
Females	0	Reference		0	Reference		0	Reference		0	Reference
Males	−2.354	−4.741, 0.034	0.053	−0.010	− 2.450, 2.429	0.993	1.105	−1.844, 4.054	0.463	1121	− 1.950, 4.192	0.474
Baseline BMI	−0.060	−0.198, 0.078	0.397	0.006	−0.138, 0.150	0.938	0.019	−0.155, 0.193	0.827	0.015	−0.166, 0.197	0.868
Sedentary time change	0.007	−0.006, 0.020	0.270	0.002	−0.007, 0.011	0.610	0.001	−0.010, 0.012	0.876	0.001	−0.010, 0.012	0.856
Nutritional intervention
OO	0	Reference		0	Reference		0	Reference		0	Reference
DieTBra	−5.001	−7.135, −2.867	< 0.001	0.110	−1.430, 1.650	0.889	−1.390	−3.252, 0.472	0.143	−1.510	−3.448, 0.429	0.127
DieTBra+OO	−4.397	−6.474, −2.321	< 0.001	0.001	−1.468, 1.468	1.000	−1.502	−3.277, 0.273	0.097	−1.574	−3.423, 0.274	0.095
Pro12Ala polymorphism
ProPro	0	Reference		0	Reference		0	Reference		0	Reference
12Ala carriers	0.508	−1.823, 2.839	0.669	−2.338	−4.067, −0.608	0.008	2.917	0.825, 5.008	0.006	3.122	0.945, 5.301	0.005

Dependent variables: 12thweek measurement – baseline measurement. OO olive oil group, DieTBra traditional Brazilian diet group, DieTBra + OO traditional Brazilian diet plus olive oil group, BMI Body Mass Index
*General linear models were adjusted for age, gender, baseline BMI and change in sedentary time. When interactions were tested (SNP x nutritional intervention, gender x nutritional intervention), the P value was not significant (P > 0.05). Data for the outcome fat mass was not significant

ISSN: 1743-7075