Fig. 1

Switching from HFC to HFP, LFC, or LFP improves fasted blood glucose levels and blood glucose tolerance. (a) Mice were fed either LFC or HFC for 12 weeks and then HFC fed mice were switched to HFP, LFC or LFP for 4 weeks. Fasted (16 h) blood glucose was measured. Results are expressed as means ± s.e.m.; n = 3. Points without a common superscript are different (p < 0.05). # indicates significance versus LFC control (p < 0.05). (b) Mice were fed either LFC or HFC for 12 weeks and then HFC fed mice were switched to HFP, LFC or LFP for 4 weeks. Intraperitoneal glucose tolerance was measured over 180 min. Results are expressed as means ± s.e.m. of area under the curve (AUC) of blood glucose versus time; n = 3. (c) Blood glucose levels from mice treated in (b). Results are expressed as means ± s.e.m. of mg/dL of blood glucose; n = 3. Points without a common superscript are different (p < 0.05). # indicates significance versus LFC control (p < 0.05)