Metabolomic profiles associated with bone mineral density in US Caucasian women

Nutrition & Metabolism

Table 2 The differential metabolites between low and high BMD groups

Metabolite	Class	m/z	RT	VIP score	OR (95%CI)^a	P value
γ-Aminobutanoate	Amino Acid	104.0711	0.81	2.31	0.65 (0.37–1.06)	0.0965
Threonine	Amino Acid	120.0654	1.01	2.44	0.54 (0.31–0.91)	0.0256
L-Cysteine	Amino Acid	122.0267	0.76	1.77	0.44 (0.22–0.79)	0.0115^b
Taurine	Amino Acid	124.0072	0.72	2.51	1.99 (1.21–3.44)	0.0086^b
L-Glutamic acid	Amino Acid	146.0458	0.76	1.63	2.18 (1.3–3.94)	0.0055^b
Stachydrine	Amino Acid Derivative	144.1017	1.23	2.92	0.5 (0.29–0.84)	0.0104^b
Formylkynurenine	Amino Acid Derivative	237.0865	10.71	1.90	2.51 (1.35–5.16)	0.0065^b
Isovalerylcarnitine	Lipid	246.1695	8.19	2.30	0.48 (0.26–0.82)	0.0105^b
Ursodeoxycholic acid	Lipid	357.278	11.53	1.30	2.69 (1.48–5.41)	0.0025^b
LysoPE (16:0)	Lipid	452.2782	13.42	2.08	1.48 (0.93–2.45)	0.1036
Cholic acid	Lipid	453.2858	11.21	2.20	0.62 (0.36–1.00)	0.0557
Tauroursodeoxycholic acid	Lipid	498.2894	9.99	1.65	2.18 (1.3–3.88)	0.0049^b
Succinate	Organic Acid	117.0202	2.23	1.75	2.09 (1.23–3.73)	0.0085^b
N-Acetylneuraminic acid	Organic Acid	308.0989	0.79	2.40	2.15 (1.25–3.98)	0.0092^b

CI Confidence interval, RT Retention time, VIP Variable importance in projection
^aAssociated with one unit increase in the metabolite
^bFDR q values ≤0.2

ISSN: 1743-7075