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Table 1 GABA causes an increment in the antioxidant status of RINm5F exposed to H2O2*

From: Protective effects of γ-aminobutyric acid against H2O2-induced oxidative stress in RIN-m5F pancreatic cells

 

T-AOC

CAT

SOD

GSH-Px

MDA

(U/mg prot)

(U/mg prot)

(U/mg prot)

(U/mg prot)

(nM/mg prot)

Control

1.20 ± 0.15d

8.65 ± 0.63d

16.31 ± 1.21d

138.91 ± 11.02d

3.18 ± 0.26e

H2O2

0.26 ± 0.06a

2.30 ± 0.19a

4.49 ± 0.45a

57.31 ± 5.97a

6.50 ± 0.52a

H2O2 + 50 μmol/L GABA

0.40 ± 0.05a

2.57 ± 0.45ab

5.57 ± 0.48a

63.39 ± 4.02a

6.17 ± 0.54ab

H2O2 + 100 μmol/L GABA

0.59 ± 0.07b

3.19 ± 0.22b

8.29 ± 0.57b

75.80 ± 8.31b

5.52 ± 0.29bc

H2O2 + 200 μmol/L GABA

0.76 ± 0.07c

4.71 ± 0.38c

11.71 ± 0.74c

91.00 ± 10.07c

5.02 ± 0.29cd

  1. Control, control medium; H2O2, medium containing 100 μmol/L H2O2; H2O2 + (50 μmol/L, 100 μmol/L, 200 μmol/L) GABA, medium containing 100 μmol/L H2O2 and GABA; T-AOC Total antioxidant capacity, CAT Catalase, SOD, Superoxide dismutase, GSH-PX Glutathione peroxidase, MDA Malondialdehyde
  2. *Values are expressed as mean ± SD (n = 8) of three separate experiments. Means with different superscript letters within a same column gare significantly different (P < 0.05)