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Table 1 GABA causes an increment in the antioxidant status of RINm5F exposed to H2O2*

From: Protective effects of γ-aminobutyric acid against H2O2-induced oxidative stress in RIN-m5F pancreatic cells

  T-AOC CAT SOD GSH-Px MDA
(U/mg prot) (U/mg prot) (U/mg prot) (U/mg prot) (nM/mg prot)
Control 1.20 ± 0.15d 8.65 ± 0.63d 16.31 ± 1.21d 138.91 ± 11.02d 3.18 ± 0.26e
H2O2 0.26 ± 0.06a 2.30 ± 0.19a 4.49 ± 0.45a 57.31 ± 5.97a 6.50 ± 0.52a
H2O2 + 50 μmol/L GABA 0.40 ± 0.05a 2.57 ± 0.45ab 5.57 ± 0.48a 63.39 ± 4.02a 6.17 ± 0.54ab
H2O2 + 100 μmol/L GABA 0.59 ± 0.07b 3.19 ± 0.22b 8.29 ± 0.57b 75.80 ± 8.31b 5.52 ± 0.29bc
H2O2 + 200 μmol/L GABA 0.76 ± 0.07c 4.71 ± 0.38c 11.71 ± 0.74c 91.00 ± 10.07c 5.02 ± 0.29cd
  1. Control, control medium; H2O2, medium containing 100 μmol/L H2O2; H2O2 + (50 μmol/L, 100 μmol/L, 200 μmol/L) GABA, medium containing 100 μmol/L H2O2 and GABA; T-AOC Total antioxidant capacity, CAT Catalase, SOD, Superoxide dismutase, GSH-PX Glutathione peroxidase, MDA Malondialdehyde
  2. *Values are expressed as mean ± SD (n = 8) of three separate experiments. Means with different superscript letters within a same column gare significantly different (P < 0.05)