Fig. 1

Overview of study design with focus on diet paradigm. Hatched study months indicate the two in vivo assessment periods: mid-study and before termination. Approximate timing common for all three cohorts. 5B4L and 9G4U indicate the two different fat/fructose/cholesterol-rich diets used. Nutrient profile differences between the two diets can be found in the text. SD = fed standard chow, FFC = fed fat/fructose/cholesterol-rich diet, FFC/SD = dietary normalization