| |
SD n = 7
|
FFC n = 14
|
FFC/SD n = 14
|
Overall P value
|
|---|
|
Triglyceride (mM)
|
|
Mid-study
|
0.38 (0.29–0.41)
|
0.57 (0.37–0.76)*
|
0.48 (0.33–0.52)
|
0.04
|
|
Termination
|
0.34 (0.29–0.35)b
|
0.63 (0.54–0.88)h**
|
0.36 (0.32–0.45)g†††
|
<.0001
|
|
Total cholesterol (mM)
|
|
Mid-study
|
2.0 (1.6–2.2)
|
14.1 (11.1–22.1)***
|
14.6 (11.2–18.7)***
|
0.0003
|
|
Termination
|
1.7 (1.6–2.2)b
|
11.9 (11.0–13.2)h***
|
1.9 (1.6–2.0)g††††
|
<.0001
|
|
Glucose (mM)
|
|
Mid-study
|
3.8 (3.5–4.0)
|
4.0 (3.9–4.2)h
|
3.9 (3.6–4.2)f
|
0.3
|
|
Termination
|
3.4 (3.2–3.6)b
|
3.7 (3.6–3.9)
|
3.8 (3.7–4.0)e
|
0.05
|
|
KG (min−1)
|
|
Mid-study
|
3.1 (2.8–4.9)
|
2.2 (1.9–2.4)h**
|
2.1 (1.9–2.1)**
|
0.005
|
|
Termination
|
3.2 (2.7–3.5)b
|
2.1 (1.8–2.4)h**
|
3.2 (2.5–3.6)†
|
0.01
|
|
AUCInsulin (pM*min)
|
|
Mid-study
|
6983 (6344–12,602)
|
10,519 (9780–16,901)h
|
11,834 (10996–14,716)d
|
0.2
|
|
Termination
|
12,573 (11507–20,683)a
|
27,168 (17204–35,562)h
|
24,032 (20478–28,147)c
|
0.07
|
- Data is presented as median and interquartile range (25th–75th)
- SD fed standard chow, FFC fed fat/fructose/cholesterol-rich diet, FFC/SD dietary normalization, KG intravenous glucose tolerance index, AUCInsulin area under the curve of insulin
- *P < 0.05; **P < 0.01; ***P < 0.001, significantly different from SD, †P < 0.05; †††P < 0.001; ††††P < 0.0001, significantly different from FFC
- a n = 5
- b n = 6
- c n = 8
- d n = 9
- e n = 10
- f n = 11
- g n = 12
- h n = 13
