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Table 2 Circulating lipids and glucose metabolism markers

From: Dietary normalization from a fat, fructose and cholesterol-rich diet to chow limits the amount of myocardial collagen in a Göttingen Minipig model of obesity

 

SD n = 7

FFC n = 14

FFC/SD n = 14

Overall P value

Triglyceride (mM)

 Mid-study

0.38 (0.29–0.41)

0.57 (0.37–0.76)*

0.48 (0.33–0.52)

0.04

 Termination

0.34 (0.29–0.35)b

0.63 (0.54–0.88)h**

0.36 (0.32–0.45)g†††

<.0001

Total cholesterol (mM)

 Mid-study

2.0 (1.6–2.2)

14.1 (11.1–22.1)***

14.6 (11.2–18.7)***

0.0003

 Termination

1.7 (1.6–2.2)b

11.9 (11.0–13.2)h***

1.9 (1.6–2.0)g††††

<.0001

Glucose (mM)

 Mid-study

3.8 (3.5–4.0)

4.0 (3.9–4.2)h

3.9 (3.6–4.2)f

0.3

 Termination

3.4 (3.2–3.6)b

3.7 (3.6–3.9)

3.8 (3.7–4.0)e

0.05

KG (min−1)

 Mid-study

3.1 (2.8–4.9)

2.2 (1.9–2.4)h**

2.1 (1.9–2.1)**

0.005

 Termination

3.2 (2.7–3.5)b

2.1 (1.8–2.4)h**

3.2 (2.5–3.6)

0.01

AUCInsulin (pM*min)

 Mid-study

6983 (6344–12,602)

10,519 (9780–16,901)h

11,834 (10996–14,716)d

0.2

 Termination

12,573 (11507–20,683)a

27,168 (17204–35,562)h

24,032 (20478–28,147)c

0.07

  1. Data is presented as median and interquartile range (25th–75th)
  2. SD fed standard chow, FFC fed fat/fructose/cholesterol-rich diet, FFC/SD dietary normalization, KG intravenous glucose tolerance index, AUCInsulin area under the curve of insulin
  3. *P < 0.05; **P < 0.01; ***P < 0.001, significantly different from SD, P < 0.05; †††P < 0.001; ††††P < 0.0001, significantly different from FFC
  4. a n = 5
  5. b n = 6
  6. c n = 8
  7. d n = 9
  8. e n = 10
  9. f n = 11
  10. g n = 12
  11. h n = 13