Dietary normalization from a fat, fructose and cholesterol-rich diet to chow limits the amount of myocardial collagen in a Göttingen Minipig model of obesity

Table 3 Correlation analyses

	BW (kg)	Body fat (%)	LBM (kg)	HW (g)	Plasma TC (mM)	Plasma TG (mM)	AUC_Insulin (pmol/min)	K_G (min⁻¹)
Biochemical collagen (μg/mg)	r_s = 0.25 P = 0.1	r_s = 0.32 P = 0.06	r_s = −0.29 P = 0.09	r_s = 0.015 P = 0.9	r_s = 0.31 P = 0.08	r_s = 0.30 P = 0.08	r_s = 0.13 P = 0.5	r_s = −0.35 P = 0.06
Collagen fraction area	r = 0.29 P = 0.09	r = 0.29 P = 0.09	r = −0.11 P = 0.5	r = 0.13 P = 0.5	r = 0.32 P = 0.07	r = 0.17 P = 0.3	r = 0.25 P = 0.2	r = −0.27 P = 0.2
Biochemical TG (μmol/g)	r_s = 0.45 P = 0.007**	r_s = 0.35 P = 0.04*	r_s = 0.18 P = 0.3	r_s = 0.35 P = 0.04*	r_s = 0.025 P = 0.9	r_s = 0.37 P = 0.03*	r_s = 0.12 P = 0.6	r_s = 0.006 P = 1.0
Cardiomyocyte diameter (μm)	r = 0.54 P = 0.0008***	r = 0.53 P = 0.001**	r = −0.046 P = 0.8	r = 0.51 P = 0.002**	r = 0.23 P = 0.2	r = 0.11 P = 0.5	r = 0.26 P = 0.2	r = −0.15 P = 0.4

BW body weight, LBM lean body mass, HW heart weight, TC total cholesterol, TG triglyceride, AUC_Insulin area under the curve of insulin, K_G intravenous glucose tolerance index; *P < 0.05; **P < 0.01; ***P < 0.001.

ISSN: 1743-7075