Fig. 1

Representative ultrasound images from mice treated with HFD or DEN+HFD at 2 months, 6 months and 10 months. On visual pattern, increased intensity of the echogenicity due to fatty infiltration was found in the HFD treated mice and the DEN+HFD treated mice at month 2, month 6 and month 10. Hyperechoic mass detected in liver parenchyma in DEN+HFD treated mice at month 6 and month 10. m: month; white arrow head: hyperechoic mass