Table 1 Receptors for AGEs
AGE Receptors | Cell Types | Function |
|---|---|---|
RAGE | Monocytes/Macrophages, T-lymphocytes, endothelial cells, mesangial cells, fibroblasts, smooth muscle cells, neuronal cells | Endocytosis, signalling (cell activation), generation of ROS, inflammatory response |
AGER1 | Monocytes/Macrophages, T-lymphocytes, endothelial cells, mesangial cells, fibroblasts, smooth muscle cells, neuronal cells | Endocytic uptake and degradation of AGEs/AGE-modified proteins, protective against oxidative stress |
AGER2 | Monocytes/Macrophages, T-lymphocytes, endothelial cells, mesangial cells, fibroblasts, smooth muscle cells, neuronal cells | Signalling (cell activation), regulatory subunit of glucosidase II |
AGER3 | Monocytes/Macrophages, T-lymphocytes, endothelial cells, mesangial cells, fibroblasts, smooth muscle cells, neuronal cells | Signalling (cell activation) |
SR-A | Monocytes/Macrophages, dendritic cells, endothelial cells | Endocytic uptake and degradation of AGEs/AGE-modified proteins and modified LDL |
SR-B | Platelets, endothelial cells, epithelial cells, adipocytes, lymphocytes | Endocytic uptake and degradation of AGEs/AGE-modified proteins, cell adhesion, regulator of fatty acid transport |
SR-BI | Tissues that are active in selective uptake of high density lipoprotein (HDL) | Selective uptake of HDL, endocytic uptake and degradation of AGEs |
SR-E | Macrophages, endothelial cells, smooth muscle cells | Signalling, endocytic uptake and degradation of OxLDL |
FEEL-1/FEEL-2 | Monocytes/Macrophages, endothelial cells | Endocytic uptake and degradation of AGEs/AGE-modified proteins, hyaluronic acid and AcLDL |