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Table 2 Effect of the ANGPTL4 SNPs on the risk of CAD and IS, angiographic severity of CAD

From: ANGPTL4 variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses

Genotype Control (% ) CAD (% ) IS (% ) OR (95% CI)CAD P CAD OR (95% CI)IS P IS OR (95% CI)AS P AS
rs4076317
 GG 7.3 7.6 7.6 1.00   1.00   1.00  
 CG 39.7 39.4 41.0 1.01 (0.61-1.67) 0.971 0.83 (0.50-1.40) 0.493 1.20 (0.58-2.50) 0.621
 CC 53.0 53.0 51.4 0.94 (0.56-1.56) 0.797 0.89 (0.53-1.48) 0.656 0.98 (0.47-2.04) 0.947
P   0.982 0.867       
PHWE 0.925 0.882 0.755       
 Any C vs. GG 92.7 92.4 92.4 0.92 (0.56-1.52) 0.893 0.83 (0.50-1.37) 0.491 1.10 (0.54-2.22) 0.800
 Any G vs. CC 47.0 47.0 48.6 0.94 (0.72-1.21) 0.611 0.96 (0.74-1.25) 0.778 0.81 (0.56-1.19) 0.289
rs7255436
 AA 1.3 1.2 0.7 1.00   1.00   1.00  
 AC 15.3 15.2 14.2 0.91 (0.27-3.08) 0.885 1.06 (0.28-4.07) 0.932 3.68 (0.80-17.06) 0.095
 CC 83.4 83.6 85.1 0.81 (0.23-2.83) 0.742 0.98 (0.25-3.89) 0.974 4.22 (0.85-21.00) 0.078
P   0.995 0.581       
PHWE 0.168 0.174 0.669       
 Any C vs. AA 98.7 98.8 99.3 0.86 (0.27-2.79) 0.804 1.05 (0.27-4.03) 0.944 3.75 (0.81-17.36) 0.090
 Any A vs. CC 16.6 16.4 14.9 0.92 (0.65-1.29) 0.615 0.92 (0.65-1.32) 0.659 1.00 (0.59-1.68) 0.991
rs1044250
 TT 0.2 0.3 0.2 1.00   1.00   1.00  
 CT 4.2 6.0 6.1 0.87 (0.06-12.52) 0.921 1.34 (0.06-29.65) 0.944 3.16 (0.19-52.71) 0.424
 CC 95.6 93.7 93.7 1.19 (0.08-18.09) 0.900 2.21 (0.10-51.65) 0.621 4.00 (0.21-75.39) 0.355
P   0.336 0.346       
PHWE 0.170 0.077 0.556       
 Any C vs. TT 99.8 99.7 99.8 0.87 (0.06-12.52) 0.921 1.38 (0.06-30.53) 0.840 3.19 (0.19-53.34) 0.419
 Any T vs. CC 4.4 6.3 6.3 1.35 (0.76-2.42) 0.307 1.61 (0.90-2.90) 0.111 1.14 (0.50-2.62) 0.750
rs2967605
 CC 12.6 17.8 17.9 1.00   1.00   1.00  
 CT 48.8 44.2 44.7 0.62 (0.42-0.91) 0.015 0.48 (0.32-0.71) <0.001 0.72 (0.43-1.27) 0.279
 TT 38.6 38.0 37.4 0.78 (0.52-1.16) 0.222 0.62 (0.41-0.93) 0.020 1.05 (0.60-1.86) 0.856
P   0.043 0.047       
PHWE 0.267 0.062 0.102       
 Any T vs. CC 87.4 82.2 82.1 0.68 (0.47-0.99) 0.043 0.55 (0.38-0.80) 0.020 0.86 (0.52-1.44) 0.570
 Any C vs. TT 61.4 62.0 62.6 0.88 (0.68-1.16) 0.380 1.05 (0.80-1.37) 0.736 0.76 (0.51-1.14) 0.183
  1. HWE Hardy-Weinberg equilibrium, CAD coronary artery disease, IS ischemic stroke, AS angiographic severity of CAD. Adjusted for age, gender, BMI, smoking status, alcohol consumption, hypertension, hyperlipidemia and T2DM