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Table 2 Effect of the ANGPTL4 SNPs on the risk of CAD and IS, angiographic severity of CAD

From: ANGPTL4 variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses

Genotype

Control (% )

CAD (% )

IS (% )

OR (95% CI)CAD

P CAD

OR (95% CI)IS

P IS

OR (95% CI)AS

P AS

rs4076317

 GG

7.3

7.6

7.6

1.00

 

1.00

 

1.00

 

 CG

39.7

39.4

41.0

1.01 (0.61-1.67)

0.971

0.83 (0.50-1.40)

0.493

1.20 (0.58-2.50)

0.621

 CC

53.0

53.0

51.4

0.94 (0.56-1.56)

0.797

0.89 (0.53-1.48)

0.656

0.98 (0.47-2.04)

0.947

 P

 

0.982

0.867

      

 PHWE

0.925

0.882

0.755

      

 Any C vs. GG

92.7

92.4

92.4

0.92 (0.56-1.52)

0.893

0.83 (0.50-1.37)

0.491

1.10 (0.54-2.22)

0.800

 Any G vs. CC

47.0

47.0

48.6

0.94 (0.72-1.21)

0.611

0.96 (0.74-1.25)

0.778

0.81 (0.56-1.19)

0.289

rs7255436

 AA

1.3

1.2

0.7

1.00

 

1.00

 

1.00

 

 AC

15.3

15.2

14.2

0.91 (0.27-3.08)

0.885

1.06 (0.28-4.07)

0.932

3.68 (0.80-17.06)

0.095

 CC

83.4

83.6

85.1

0.81 (0.23-2.83)

0.742

0.98 (0.25-3.89)

0.974

4.22 (0.85-21.00)

0.078

 P

 

0.995

0.581

      

 PHWE

0.168

0.174

0.669

      

 Any C vs. AA

98.7

98.8

99.3

0.86 (0.27-2.79)

0.804

1.05 (0.27-4.03)

0.944

3.75 (0.81-17.36)

0.090

 Any A vs. CC

16.6

16.4

14.9

0.92 (0.65-1.29)

0.615

0.92 (0.65-1.32)

0.659

1.00 (0.59-1.68)

0.991

rs1044250

 TT

0.2

0.3

0.2

1.00

 

1.00

 

1.00

 

 CT

4.2

6.0

6.1

0.87 (0.06-12.52)

0.921

1.34 (0.06-29.65)

0.944

3.16 (0.19-52.71)

0.424

 CC

95.6

93.7

93.7

1.19 (0.08-18.09)

0.900

2.21 (0.10-51.65)

0.621

4.00 (0.21-75.39)

0.355

 P

 

0.336

0.346

      

 PHWE

0.170

0.077

0.556

      

 Any C vs. TT

99.8

99.7

99.8

0.87 (0.06-12.52)

0.921

1.38 (0.06-30.53)

0.840

3.19 (0.19-53.34)

0.419

 Any T vs. CC

4.4

6.3

6.3

1.35 (0.76-2.42)

0.307

1.61 (0.90-2.90)

0.111

1.14 (0.50-2.62)

0.750

rs2967605

 CC

12.6

17.8

17.9

1.00

 

1.00

 

1.00

 

 CT

48.8

44.2

44.7

0.62 (0.42-0.91)

0.015

0.48 (0.32-0.71)

<0.001

0.72 (0.43-1.27)

0.279

 TT

38.6

38.0

37.4

0.78 (0.52-1.16)

0.222

0.62 (0.41-0.93)

0.020

1.05 (0.60-1.86)

0.856

 P

 

0.043

0.047

      

 PHWE

0.267

0.062

0.102

      

 Any T vs. CC

87.4

82.2

82.1

0.68 (0.47-0.99)

0.043

0.55 (0.38-0.80)

0.020

0.86 (0.52-1.44)

0.570

 Any C vs. TT

61.4

62.0

62.6

0.88 (0.68-1.16)

0.380

1.05 (0.80-1.37)

0.736

0.76 (0.51-1.14)

0.183

  1. HWE Hardy-Weinberg equilibrium, CAD coronary artery disease, IS ischemic stroke, AS angiographic severity of CAD. Adjusted for age, gender, BMI, smoking status, alcohol consumption, hypertension, hyperlipidemia and T2DM
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Nutrition & Metabolism

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