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Table 6 Effects of the ANGPTL4 rs4076317 SNP on serum lipid levels at baseline and response to atorvastatin therapy in hyperlipidemia

From: ANGPTL4 variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses

Group TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoA1(g/L) ApoB(g/L)
Total patient (n = 724)
 Before 5.33±1.01 2.12±1.39 1.44±0.61 3.17±0.93 1.19±0.35 1.04±0.23
 After 4.41±0.46 1.05±0.32 1.48±0.49 2.59±0.46 1.01±0.23 0.81±0.15
F 22.305 20.185 1.376 15.042 11.565 22.538
P 0.000 0.000 0.169 0.000 0.000 0.000
Control (n = 253)
 Before 5.62±0.71 1.74±1.51 1.98±0.54 3.24±0.72 1.47±0.25 1.03±0.19
 After 4.67±0.30 0.96±0.31 1.93±0.43 2.61±0.40 1.42±0.21 0.87±0.13
F 19.604 8.049 1.152 12.166 2.436 11.055
P 0.000 0.000 0.250 0.000 0.015 0.000
CAD (n = 248)
 Before 5.14±1.16 2.29±1.18 1.13±0.35 3.08±1.08 1.06±0.35 1.05±0.28
 After 4.29±0.48 1.12±0.31 1.20±0.31 2.61±0.52 0.97±0.25 0.78±0.16
F 10.663 15.102 2.358 6.175 3.295 13.185
P 0.000 0.000 0.019 0.000 0.001 0.000
IS (n = 223)
 Before 5.22±1.02 2.36±1.37 1.18±0.49 3.19±0.96 1.03±0.21 1.06±0.22
 After 4.26±0.47 1.08±0.32 1.30±0.31 2.53±0.45 1.04±0.21 0.82±0.15
F 12.765 13.587 3.091 9.296 0.503 13.460
P 0.000 0.000 0.002 0.000 0.615 0.000
CC genotype (n = 381)
 Before 5.34±0.95 2.18±1.50 1.45±0.61 3.15±0.89 1.20±0.36 1.03±0.21
 After 4.56±0.40 1.07±0.31 1.52±0.49 2.70±0.44 1.04±0.24 0.82±0.15
F 14.770 14.145 1.746 8.847 7.218 15.883
P 0.000 0.000 0.081 0.000 0.000 0.000
CG genotype (n = 284)
 Before 5.29±1.00 2.04±1.11 1.42±0.63 3.18±0.94 1.19±0.34 1.06±0.25
 After 4.26±0.45 1.06±0.33 1.43±0.49 2.48±0.44 1.14±0.29 0.80±0.17
F 15.829 14.262 0.211 11.366 1.886 14.493
P 0.000 0.000 0.833 0.000 0.060 0.000
GG genotype (n = 59)
 Before 5.49±1.18 2.12±1.78 1.43±0.48 3.21±1.06 1.16±0.28 1.04±0.26
 After 4.18±0.59 0.95±0.31 1.48±0.50 2.40±0.49 1.14±0.29 0.81±0.14
F 7.627 4.974 0.554 5.327 0.381 5.983
P 0.000 0.000 0.581 0.000 0.704 0.000
  1. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B