Table 6 Effects of the ANGPTL4 rs4076317 SNP on serum lipid levels at baseline and response to atorvastatin therapy in hyperlipidemia
Group | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | ApoA1(g/L) | ApoB(g/L) |
|---|---|---|---|---|---|---|
Total patient (n = 724) | ||||||
 Before | 5.33±1.01 | 2.12±1.39 | 1.44±0.61 | 3.17±0.93 | 1.19±0.35 | 1.04±0.23 |
 After | 4.41±0.46 | 1.05±0.32 | 1.48±0.49 | 2.59±0.46 | 1.01±0.23 | 0.81±0.15 |
 F | 22.305 | 20.185 | 1.376 | 15.042 | 11.565 | 22.538 |
 P | 0.000 | 0.000 | 0.169 | 0.000 | 0.000 | 0.000 |
Control (n = 253) | ||||||
 Before | 5.62±0.71 | 1.74±1.51 | 1.98±0.54 | 3.24±0.72 | 1.47±0.25 | 1.03±0.19 |
 After | 4.67±0.30 | 0.96±0.31 | 1.93±0.43 | 2.61±0.40 | 1.42±0.21 | 0.87±0.13 |
 F | 19.604 | 8.049 | 1.152 | 12.166 | 2.436 | 11.055 |
 P | 0.000 | 0.000 | 0.250 | 0.000 | 0.015 | 0.000 |
CAD (n = 248) | ||||||
 Before | 5.14±1.16 | 2.29±1.18 | 1.13±0.35 | 3.08±1.08 | 1.06±0.35 | 1.05±0.28 |
 After | 4.29±0.48 | 1.12±0.31 | 1.20±0.31 | 2.61±0.52 | 0.97±0.25 | 0.78±0.16 |
 F | 10.663 | 15.102 | 2.358 | 6.175 | 3.295 | 13.185 |
 P | 0.000 | 0.000 | 0.019 | 0.000 | 0.001 | 0.000 |
IS (n = 223) | ||||||
 Before | 5.22±1.02 | 2.36±1.37 | 1.18±0.49 | 3.19±0.96 | 1.03±0.21 | 1.06±0.22 |
 After | 4.26±0.47 | 1.08±0.32 | 1.30±0.31 | 2.53±0.45 | 1.04±0.21 | 0.82±0.15 |
 F | 12.765 | 13.587 | 3.091 | 9.296 | 0.503 | 13.460 |
 P | 0.000 | 0.000 | 0.002 | 0.000 | 0.615 | 0.000 |
CC genotype (n = 381) | ||||||
 Before | 5.34±0.95 | 2.18±1.50 | 1.45±0.61 | 3.15±0.89 | 1.20±0.36 | 1.03±0.21 |
 After | 4.56±0.40 | 1.07±0.31 | 1.52±0.49 | 2.70±0.44 | 1.04±0.24 | 0.82±0.15 |
 F | 14.770 | 14.145 | 1.746 | 8.847 | 7.218 | 15.883 |
 P | 0.000 | 0.000 | 0.081 | 0.000 | 0.000 | 0.000 |
CG genotype (n = 284) | ||||||
 Before | 5.29±1.00 | 2.04±1.11 | 1.42±0.63 | 3.18±0.94 | 1.19±0.34 | 1.06±0.25 |
 After | 4.26±0.45 | 1.06±0.33 | 1.43±0.49 | 2.48±0.44 | 1.14±0.29 | 0.80±0.17 |
 F | 15.829 | 14.262 | 0.211 | 11.366 | 1.886 | 14.493 |
 P | 0.000 | 0.000 | 0.833 | 0.000 | 0.060 | 0.000 |
GG genotype (n = 59) | ||||||
 Before | 5.49±1.18 | 2.12±1.78 | 1.43±0.48 | 3.21±1.06 | 1.16±0.28 | 1.04±0.26 |
 After | 4.18±0.59 | 0.95±0.31 | 1.48±0.50 | 2.40±0.49 | 1.14±0.29 | 0.81±0.14 |
 F | 7.627 | 4.974 | 0.554 | 5.327 | 0.381 | 5.983 |
 P | 0.000 | 0.000 | 0.581 | 0.000 | 0.704 | 0.000 |