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Table 3 Comparison of anthropometric, metabolic and reproductive phenotypes between insulin resistant and insulin sensitive women with polycystic ovary syndrome (PCOS)

From: Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes

 

PCOS Insulin Sensitive (N = 10)

PCOS Insulin Resistant (N = 20)

P- value

Anthropometric Phenotype

 Age (years)

30.5 ± 5.0

28.0 ± 4.4

0.17

  Range, Median

23–29, 31.5

23–37, 26.5

 

 Weight (kg)

87.9 ± 15.6

110.0 ± 16.5

0.002

  Range, Median

66.7–109.8, 90.2

87.5–144.4, 109

 

 BMI (kg/m2)

33.8 ± 6.3

41.4 ± 7.7

0.01

  Range, Median

25.3–44.4, 33.6

32.6–63.9, 38.6

 

 Fat mass (%)

44.0 ± 6.7

46.6 ± 5.0

0.23

  Range, Median

34.2–54.1, 44.9

36.5–58.4, 45.9

 

 Fat-free mass (kg)

48.5 ± 5.5

58.2 ± 7.1

0.001

  Range, Median

40.2–55.8, 50.4

47.7–75.6, 57.7

 

 Fat mass (kg)

39.4 ± 12.2

51.8 ± 12.3

0.01

  Range, Median

22.8–59.4, 38.5

35.7–77.0, 48.4

 

 VAT (kg)

1.4 ± 0.79

2.4 ± 1.0

0.02

  Range, Median

0.6–3.1, 1.2

1.1–4.4, 2.6

 

Metabolic Phenotype

 Baseline RQ

0.765 ± 0.05

0.763 ± 0.04

0.93

  Range, Median

0.72–0.88, 0.745

0.71–0.83, 0.76

 

 Insulin Stimulated RQ

0.834 ± 0.06

0.801 ± 0.04

0.08

  Range, Median

0.75–0.94, 0.82

0.72–0.85, 0.795

 

 NOGM (mg/kgFFM/min)

8.79 ± 1.91

3.66 ± 1.72

< 0.0001

  Range, Median

5.6–11.8, 8.2

0.8–6.6, 4.0

 

 NOGM (mg/kgFFM+ 17.7/min)

6.39 ± 1.22

2.79 ± 1.30

0.0001

  Range, Median

4.2–8.4, 6.0

0.6–5.0, 3.0

 

 Fasting Insulin (uM/L)

10.03 ± 3.47

23.36 ± 9.70

0.003

  Range, Median

5.7–15.6, 10.3

12.2–53.2, 22.2

 

 Fasting Glucose (mg/dL)

87.30 ± 5.27

91.35 ± 7.35

0.13

  Range, Median

79.0–96.0, 87.5

77.0–105.0, 91.0

 

Reproductive Phenotype

 SHBG (nmol/L)a

33.71 ± 15.36

24.36 ± 9.52

0.05

  Range, Median

14.7–67.8, 29.5

9.7–48.5, 23.1

 

 Total Testosterone (ng/dL)a

53.88 ± 17.97

69.22 ± 40.04

0.31

  Range, Median

26.5–75, 59.5

22.0–175.5, 62.5

 

 Free Testosterone (pg/mL)a

9.89 ± 3.64

14.91 ± 6.59

0.06

  Range, Median

6.4–16.1, 8.6

6.2–27.8, 13.0

 

 Percent Free Testosteronea

1.89 ± 0.48

2.29 ± 0.43

0.04

  Range, Median

1.1–2.7, 2.0

1.5–3.1, 2.2

 

 Free Androgen Indexa

5.71 ± 2.43

9.81 ± 3.51

0.006

  Range, Median

3.1–9.7, 5.0

4.7–16.1, 10.1

 
  1. Data is expressed as mean ± standard deviation. a = values were averaged over two visits two weeks apart. VAT: visceral adipose tissue, SHBG: sex hormone-binding globulin, NOGM: non-oxidative glucose metabolism. P-value font in boldface is statistically significant