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Table 3 Comparison of anthropometric, metabolic and reproductive phenotypes between insulin resistant and insulin sensitive women with polycystic ovary syndrome (PCOS)

From: Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes

  PCOS Insulin Sensitive (N = 10) PCOS Insulin Resistant (N = 20) P- value
Anthropometric Phenotype
 Age (years) 30.5 ± 5.0 28.0 ± 4.4 0.17
  Range, Median 23–29, 31.5 23–37, 26.5  
 Weight (kg) 87.9 ± 15.6 110.0 ± 16.5 0.002
  Range, Median 66.7–109.8, 90.2 87.5–144.4, 109  
 BMI (kg/m2) 33.8 ± 6.3 41.4 ± 7.7 0.01
  Range, Median 25.3–44.4, 33.6 32.6–63.9, 38.6  
 Fat mass (%) 44.0 ± 6.7 46.6 ± 5.0 0.23
  Range, Median 34.2–54.1, 44.9 36.5–58.4, 45.9  
 Fat-free mass (kg) 48.5 ± 5.5 58.2 ± 7.1 0.001
  Range, Median 40.2–55.8, 50.4 47.7–75.6, 57.7  
 Fat mass (kg) 39.4 ± 12.2 51.8 ± 12.3 0.01
  Range, Median 22.8–59.4, 38.5 35.7–77.0, 48.4  
 VAT (kg) 1.4 ± 0.79 2.4 ± 1.0 0.02
  Range, Median 0.6–3.1, 1.2 1.1–4.4, 2.6  
Metabolic Phenotype
 Baseline RQ 0.765 ± 0.05 0.763 ± 0.04 0.93
  Range, Median 0.72–0.88, 0.745 0.71–0.83, 0.76  
 Insulin Stimulated RQ 0.834 ± 0.06 0.801 ± 0.04 0.08
  Range, Median 0.75–0.94, 0.82 0.72–0.85, 0.795  
 NOGM (mg/kgFFM/min) 8.79 ± 1.91 3.66 ± 1.72 < 0.0001
  Range, Median 5.6–11.8, 8.2 0.8–6.6, 4.0  
 NOGM (mg/kgFFM+ 17.7/min) 6.39 ± 1.22 2.79 ± 1.30 0.0001
  Range, Median 4.2–8.4, 6.0 0.6–5.0, 3.0  
 Fasting Insulin (uM/L) 10.03 ± 3.47 23.36 ± 9.70 0.003
  Range, Median 5.7–15.6, 10.3 12.2–53.2, 22.2  
 Fasting Glucose (mg/dL) 87.30 ± 5.27 91.35 ± 7.35 0.13
  Range, Median 79.0–96.0, 87.5 77.0–105.0, 91.0  
Reproductive Phenotype
 SHBG (nmol/L)a 33.71 ± 15.36 24.36 ± 9.52 0.05
  Range, Median 14.7–67.8, 29.5 9.7–48.5, 23.1  
 Total Testosterone (ng/dL)a 53.88 ± 17.97 69.22 ± 40.04 0.31
  Range, Median 26.5–75, 59.5 22.0–175.5, 62.5  
 Free Testosterone (pg/mL)a 9.89 ± 3.64 14.91 ± 6.59 0.06
  Range, Median 6.4–16.1, 8.6 6.2–27.8, 13.0  
 Percent Free Testosteronea 1.89 ± 0.48 2.29 ± 0.43 0.04
  Range, Median 1.1–2.7, 2.0 1.5–3.1, 2.2  
 Free Androgen Indexa 5.71 ± 2.43 9.81 ± 3.51 0.006
  Range, Median 3.1–9.7, 5.0 4.7–16.1, 10.1  
  1. Data is expressed as mean ± standard deviation. a = values were averaged over two visits two weeks apart. VAT: visceral adipose tissue, SHBG: sex hormone-binding globulin, NOGM: non-oxidative glucose metabolism. P-value font in boldface is statistically significant