From: Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes
PCOS Insulin Sensitive (N = 10) | PCOS Insulin Resistant (N = 20) | P- value | |
---|---|---|---|
Anthropometric Phenotype | |||
Age (years) | 30.5 ± 5.0 | 28.0 ± 4.4 | 0.17 |
Range, Median | 23–29, 31.5 | 23–37, 26.5 | |
Weight (kg) | 87.9 ± 15.6 | 110.0 ± 16.5 | 0.002 |
Range, Median | 66.7–109.8, 90.2 | 87.5–144.4, 109 | |
BMI (kg/m2) | 33.8 ± 6.3 | 41.4 ± 7.7 | 0.01 |
Range, Median | 25.3–44.4, 33.6 | 32.6–63.9, 38.6 | |
Fat mass (%) | 44.0 ± 6.7 | 46.6 ± 5.0 | 0.23 |
Range, Median | 34.2–54.1, 44.9 | 36.5–58.4, 45.9 | |
Fat-free mass (kg) | 48.5 ± 5.5 | 58.2 ± 7.1 | 0.001 |
Range, Median | 40.2–55.8, 50.4 | 47.7–75.6, 57.7 | |
Fat mass (kg) | 39.4 ± 12.2 | 51.8 ± 12.3 | 0.01 |
Range, Median | 22.8–59.4, 38.5 | 35.7–77.0, 48.4 | |
VAT (kg) | 1.4 ± 0.79 | 2.4 ± 1.0 | 0.02 |
Range, Median | 0.6–3.1, 1.2 | 1.1–4.4, 2.6 | |
Metabolic Phenotype | |||
Baseline RQ | 0.765 ± 0.05 | 0.763 ± 0.04 | 0.93 |
Range, Median | 0.72–0.88, 0.745 | 0.71–0.83, 0.76 | |
Insulin Stimulated RQ | 0.834 ± 0.06 | 0.801 ± 0.04 | 0.08 |
Range, Median | 0.75–0.94, 0.82 | 0.72–0.85, 0.795 | |
NOGM (mg/kgFFM/min) | 8.79 ± 1.91 | 3.66 ± 1.72 | < 0.0001 |
Range, Median | 5.6–11.8, 8.2 | 0.8–6.6, 4.0 | |
NOGM (mg/kgFFM+ 17.7/min) | 6.39 ± 1.22 | 2.79 ± 1.30 | 0.0001 |
Range, Median | 4.2–8.4, 6.0 | 0.6–5.0, 3.0 | |
Fasting Insulin (uM/L) | 10.03 ± 3.47 | 23.36 ± 9.70 | 0.003 |
Range, Median | 5.7–15.6, 10.3 | 12.2–53.2, 22.2 | |
Fasting Glucose (mg/dL) | 87.30 ± 5.27 | 91.35 ± 7.35 | 0.13 |
Range, Median | 79.0–96.0, 87.5 | 77.0–105.0, 91.0 | |
Reproductive Phenotype | |||
SHBG (nmol/L)a | 33.71 ± 15.36 | 24.36 ± 9.52 | 0.05 |
Range, Median | 14.7–67.8, 29.5 | 9.7–48.5, 23.1 | |
Total Testosterone (ng/dL)a | 53.88 ± 17.97 | 69.22 ± 40.04 | 0.31 |
Range, Median | 26.5–75, 59.5 | 22.0–175.5, 62.5 | |
Free Testosterone (pg/mL)a | 9.89 ± 3.64 | 14.91 ± 6.59 | 0.06 |
Range, Median | 6.4–16.1, 8.6 | 6.2–27.8, 13.0 | |
Percent Free Testosteronea | 1.89 ± 0.48 | 2.29 ± 0.43 | 0.04 |
Range, Median | 1.1–2.7, 2.0 | 1.5–3.1, 2.2 | |
Free Androgen Indexa | 5.71 ± 2.43 | 9.81 ± 3.51 | 0.006 |
Range, Median | 3.1–9.7, 5.0 | 4.7–16.1, 10.1 |