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Table 2 Adjusted odds ratios (95% confidence intervals) of NAFLD according to sex and serum SHBG quartiles using adjusted logistic regression

From: Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults

  SHBG (nmol/L) p for trend
Quartile 1 Quartile 2 Quartile 3 Quartile 4
Total (N = 2912) <  38.70 38.70–52.45 52.46–71.3 >  71.3  
 Model 1 1.00 0.38 (0.30–0.48) 0.21 (0.16–0.26) 0.09 (0.07–0.11) <  0.001
 Model 2 1.00 0.46 (0.36–0.59) 0.30 (0.23–0.38) 0.18 (0.13–0.23) <  0.001
 Model 3 1.00 0.54 (0.42–0.70) 0.38 (0.29–0.50) 0.24 (0.18–0.32) <  0.001
Females (N = 2009) <  40.65 40.65–55.70 55.71–75.80 >  75.80  
 Model 1 1.00 0.34 (0.25–0.45) 0.18 (0.14–0.24) 0.07 (0.05–0.09) <  0.001
 Model 2 1.00 0.40 (0.30–0.54) 0.24 (0.18–0.33) 0.13 (0.09–0.18) <  0.001
 Model 3 1.00 0.49 (0.36–0.67) 0.33 (0.24–0.45) 0.19 (0.13–0.27) <  0.001
Males (N = 903) <  35.50 35.50–47.10 47.11–61.00 >  61.00  
 Model 1 1.00 0.67 (0.45–1.00) 0.31 (0.21–0.46) 0.13 (0.09–0.21) <  0.001
 Model 2 1.00 0.83 (0.53–1.29) 0.47 (0.30–0.73) 0.35 (0.22–0.57) <  0.001
 Model 3 1.00 0.95 (0.59–1.53) 0.57 (0.35–0.95) 0.42 (0.23–0.77) 0.001
  1. Model 1: Adjusted for age, sex, postmenopausal status (for females) and household income
  2. Model 2: Adjusted for the variables in Model 1 plus WHR, trunk fat, current smoking and drinking, physical activity (MET), hypertension and diabetes
  3. Model 3: Adjusted for the variables in Model 2 plus serum glucose, insulin resistance (HOMA-IR), TG, HDL-C, ALT, UA, testosterone and DHEAS levels
  4. NAFLD, nonalcoholic fatty liver disease; SHBG, sex hormone-binding globulin