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Table 2 Adjusted odds ratios (95% confidence intervals) of NAFLD according to sex and serum SHBG quartiles using adjusted logistic regression

From: Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults

 

SHBG (nmol/L)

p for trend

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Total (N = 2912)

<  38.70

38.70–52.45

52.46–71.3

>  71.3

 

 Model 1

1.00

0.38 (0.30–0.48)

0.21 (0.16–0.26)

0.09 (0.07–0.11)

<  0.001

 Model 2

1.00

0.46 (0.36–0.59)

0.30 (0.23–0.38)

0.18 (0.13–0.23)

<  0.001

 Model 3

1.00

0.54 (0.42–0.70)

0.38 (0.29–0.50)

0.24 (0.18–0.32)

<  0.001

Females (N = 2009)

<  40.65

40.65–55.70

55.71–75.80

>  75.80

 

 Model 1

1.00

0.34 (0.25–0.45)

0.18 (0.14–0.24)

0.07 (0.05–0.09)

<  0.001

 Model 2

1.00

0.40 (0.30–0.54)

0.24 (0.18–0.33)

0.13 (0.09–0.18)

<  0.001

 Model 3

1.00

0.49 (0.36–0.67)

0.33 (0.24–0.45)

0.19 (0.13–0.27)

<  0.001

Males (N = 903)

<  35.50

35.50–47.10

47.11–61.00

>  61.00

 

 Model 1

1.00

0.67 (0.45–1.00)

0.31 (0.21–0.46)

0.13 (0.09–0.21)

<  0.001

 Model 2

1.00

0.83 (0.53–1.29)

0.47 (0.30–0.73)

0.35 (0.22–0.57)

<  0.001

 Model 3

1.00

0.95 (0.59–1.53)

0.57 (0.35–0.95)

0.42 (0.23–0.77)

0.001

  1. Model 1: Adjusted for age, sex, postmenopausal status (for females) and household income
  2. Model 2: Adjusted for the variables in Model 1 plus WHR, trunk fat, current smoking and drinking, physical activity (MET), hypertension and diabetes
  3. Model 3: Adjusted for the variables in Model 2 plus serum glucose, insulin resistance (HOMA-IR), TG, HDL-C, ALT, UA, testosterone and DHEAS levels
  4. NAFLD, nonalcoholic fatty liver disease; SHBG, sex hormone-binding globulin