Table 3 Adjusted odds ratios (95% confidence intervals) of NAFLD according to BMI and HOMA-IR status and serum SHBG quartiles using adjusted logistic regression
From: Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults
| Â | SHBG (nmol/L) | p for trend | |||
|---|---|---|---|---|---|
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
BMI < 24 kg/m2 (N = 1696) | <  45.03 | 45.03–60.90 | 60.91–80.98 | >  80.98 |  |
 Model 1 | 1.00 | 0.50 (0.38–0.66) | 0.23 (0.17–0.31) | 0.15 (0.11–0.21) | <  0.001 |
 Model 2 | 1.00 | 0.56 (0.42–0.75) | 0.29 (0.21–0.40) | 0.24 (0.17–0.34) | <  0.001 |
 Model 3 | 1.00 | 0.60 (0.46–0.84) | 0.35 (0.25–0.48) | 0.31 (0.21–0.45) | <  0.001 |
BMI ≥ 24 kg/m2 (N = 1216) | <  32.70 | 32.70–43.10 | 43.11–56.30 | >  56.30 |  |
 Model 1 | 1.00 | 0.53 (0.34–0.83) | 0.33 (0.21–0.51) | 0.17 (0.11–0.27) | <  0.001 |
 Model 2 | 1.00 | 0.57 (0.36–0.89) | 0.37 (0.24–0.57) | 0.21 (0.14–0.32) | <  0.001 |
 Model 3 | 1.00 | 0.70 (0.44–1.12) | 0.49 (0.30–0.78) | 0.31 (0.19–0.51) | <  0.001 |
p for interaction | – | – | – | – | 0.150 |
HOMA-IR < 2 (N = 1780) | <  45.20 | 45.20–60.10 | 60.11–79.38 | >  79.38 |  |
 Model 1 | 1.00 | 0.55 (0.42–0.72) | 0.29 (0.22–0.39) | 0.17 (0.13–0.23) | <  0.001 |
 Model 2 | 1.00 | 0.64 (0.49–0.85) | 0.40 (0.29–0.54) | 0.32 (0.23–0.44) | <  0.001 |
 Model 3 | 1.00 | 0.67 (0.50–0.89) | 0.43 (0.31–0.59) | 0.34 (0.24–0.49) | <  0.001 |
HOMA-IR ≥ 2 (N = 1132) | <  31.50 | 31.50–41.60 | 41.61–55.68 | >  55.68 |  |
 Model 1 | 1.00 | 0.76 (0.47–1.21) | 0.41 (0.27–0.64) | 0.16 (0.10–0.25) | <  0.001 |
 Model 2 | 1.00 | 0.84 (0.52–1.36) | 0.46 (0.29–0.73) | 0.21 (0.14–0.33) | <  0.001 |
 Model 3 | 1.00 | 0.83 (0.50–1.36) | 0.43 (0.27–0.70) | 0.22 (0.13–0.36) | <  0.001 |
p for interaction | – | – | – | – | 0.021 |