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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice

Fig. 6

Intermittent FMD improves hyperglycemia in type 1 diabetic mouse model. a Experimental scheme to determine effects of the FMD in T1D in STZ-treated mice. Six-week-old male C57BL/6 mice were assigned to two groups: control and FMD (n = 6 for control and n = 7 for FMD). STZ (40 mg/kg) was administered intraperitoneally for five consecutive days. An equal volume of citrate buffer was injected into control mice. Each FMD cycle entails 7 days of FMD and 7 days of ad libitum feeding (AL). During AL period, the mice had free access to normal chow. b Body weight. c Blood glucose levels. Blood samples were collected on the last day of each cycle. Mice were fasted for 6 h (morning fasting) before glucose measurements. d Immunostaining of pancreatic sections to detect expression of insulin and glucagon. Scale bar: 20 μm. The percentage of β cells and α cells per islet is shown in the lower panel. Data are expressed as the mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001

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